Evidence map›Paper›PMID 30889893›Full record

ArticleGenes2019

Gene Expression Networks Across Multiple Tissues Are Associated with Rates of Molecular Evolution in Wild House Mice.

Katya L Mack, Megan Phifer-Rixey, Bettina Harr, Michael W Nachman

Abstract read
In one paragraph

Article in Genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Repeated global adaptation across plant species.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Gene expression plasticity and desert adaptation in house mice.Evolution; international journal of organic evolution · 2021
    Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Katya L MackDepartment of Integrative Biology and Museum of Vertebrate Zoology, University of California, Berkeley, CA 94720, USA. katyamack@berkeley.edu.
Megan Phifer-RixeyDepartment of Biology, Monmouth University, West Long Branch, NJ 07764, USA. mphiferr@monmouth.edu.ORCID 0000-0002-3804-6229
Bettina HarrMax-Planck-Institute for Evolutionary Biology, Plön 24306, Germany. bettina.harr@mac.com.
Michael W NachmanDepartment of Integrative Biology and Museum of Vertebrate Zoology, University of California, Berkeley, CA 94720, USA. mnachman@berkeley.edu.ORCID 0000-0003-4321-5135

Funding

Natural selection and DNA sequence variation in MusR01GM074245 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI NACHMAN, MICHAEL W. · 2005 to 2015
$3.0M
The genomic basis of environmental adaptation in miceR01GM127468 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI NACHMAN, MICHAEL W. · 2018 to 2021
$1.3M
NIH HHS R01 GM074245NIH HHS R01 GM127468
6 · The paper itself

Abstract

Interactions between genes can influence how selection acts on sequence variation. In gene regulatory networks, genes that affect the expression of many other genes may be under stronger evolutionary constraint than genes whose expression affects fewer partners. While this has been studied for individual tissue types, we know less about the effects of regulatory networks on gene evolution across different tissue types. We use RNA-sequencing and genomic data collected from

Indexed as

Gene Regulatory NetworksAnimalsEvolution, MolecularGene Expression ProfilingGene Expression RegulationGenomicsMiceOrgan SpecificitySelection, GeneticSequence Analysis, RNATissue Distributionco-expressiongene regulationhouse mice

Identifiers

PMID30889893
PMCPMC6470930

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.