Evidence map›Paper›PMID 30889803›Full record

ReviewInternational journal of molecular sciences2019

Matrix Metalloproteinases in Pulmonary and Central Nervous System Tuberculosis-A Review.

Ursula K Rohlwink, Naomi F Walker, Alvaro A Ordonez, Yifan J Li, Elizabeth W Tucker, Paul T Elkington, Robert J Wilkinson, Katalin A Wilkinson

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 58 citations in OpenAlex.

  1. Doxycycline host-directed therapy in human pulmonary tuberculosis.The Journal of clinical investigation · 2021
    Trial
  2. A pilot metabolomics study of tuberculosis immune reconstitution inflammatory syndrome.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2019
    Trial
  3. Review
  4. iScience · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. An Improved Diagnostic of theDiagnostics (Basel, Switzerland) · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Ursula K RohlwinkNeuroscience Institute, University of Cape Town, Faculty of Health Sciences, Anzio Road, Observatory 7925, South Africa. uk.rohlwink@uct.ac.za.ORCID 0000-0002-4469-4935
Naomi F WalkerTB Centre and Department of Clinical Research, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK. Naomi.Walker@lshtm.ac.uk.
Alvaro A OrdonezDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. aordone2@jhmi.edu.ORCID 0000-0002-8571-0655
Yifan J LiFaculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, South Africa. joshualyf17@gmail.com.ORCID 0000-0002-1349-3188
Elizabeth W TuckerCenter for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. etucker9@jhmi.edu.
Paul T ElkingtonNIHR Biomedical Research Centre, School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK. P.Elkington@soton.ac.uk.
Robert J WilkinsonWellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa. r.j.wilkinson@imperial.ac.uk.ORCID 0000-0002-2753-1800
Katalin A WilkinsonWellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa. Katalin.Wilkinson@crick.ac.uk.ORCID 0000-0002-9796-2040
University of Cape Town · ZAJohns Hopkins University · USNIHR Southampton Biomedical Research Centre · GBUniversity of London · GB

Funding

Novel Imaging Tracers for Rapid and Noninvasive Assessment of Bacterial InfectionR01EB020539 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2014 to 2018
$3.6M
Molecular Imaging for Pulmonary Infections and InflammationR01HL131829 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2016 to 2018
$2.2M
Medical Research Council MR/P023754/1NHLBI NIH HHS R01 HL131829NIBIB NIH HHS R01 EB020539
6 · The paper itself

Abstract

Tuberculosis (TB) remains the single biggest infectious cause of death globally, claiming almost two million lives and causing disease in over 10 million individuals annually. Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes with various physiological roles implicated as key factors contributing to the spread of TB. They are involved in the breakdown of lung extracellular matrix and the consequent release of

Indexed as

BiomarkersHumansMatrix MetalloproteinasesModels, BiologicalTuberculosis, Central Nervous SystemTuberculosis, MeningealTuberculosis, PulmonaryBiomarkersMatrix Metalloproteinasesadultcentral nervous systemextracellular matrix breakdownHIV-TB-associated IRISlungmatrix metalloproteinasespediatrictuberculosistuberculous meningitis

Identifiers

PMID30889803
PMCPMC6471445
OpenAlexW2921403643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.