Evidence map›Paper›PMID 30889792›Full record

ArticleMolecules (Basel, Switzerland)2019

Non-Targeted Metabolomic Analysis of Methanolic Extracts of Wild-Simulated and Field-Grown American Ginseng.

Hongqiang Lin, Hailin Zhu, Jing Tan, Han Wang, Qinghai Dong, Fulin Wu, Yunhe Liu, Pingya Li, Jinping Liu

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Regulatory Effects of Companion Plants (Maize (Plants (Basel, Switzerland) · 2025
    Article
  3. Characterization of Ginsenosides from the Root ofMolecules (Basel, Switzerland) · 2023
    Article
  4. Article
  5. Article
  6. Phytochemical analysis ofJournal of ginseng research · 2021
    Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hongqiang LinResearch Center of Natural Drug, School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China. linhq17@mails.jlu.edu.cn.
Hailin ZhuResearch Center of Natural Drug, School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China. 13578965875@163.com.
Jing TanResearch Center of Natural Drug, School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China. tanjing17@mails.jlu.edu.cn.
Han WangResearch Center of Natural Drug, School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China. hanw17@mails.jlu.edu.cn.
Qinghai DongResearch Center of Natural Drug, School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China. dongqh17@mails.jlu.edu.cn.
Fulin WuResearch Center of Natural Drug, School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China. wufl17@mails.jlu.edu.cn.
Yunhe LiuResearch Center of Natural Drug, School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China. lyh133700@163.com.
Pingya LiResearch Center of Natural Drug, School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China. lipy@jlu.edu.cn.
Jinping LiuResearch Center of Natural Drug, School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China. liujp@jlu.edu.cn.ORCID 0000-0003-4020-879X

Funding

Graduate Innovation Fund of Jilin University 101832018C085
6 · The paper itself

Abstract

Aiming at revealing the structural diversity of secondary metabolites and the different patterns in wild-simulated American ginseng (WsAG) and field-grown American ginseng (FgAG), a comprehensive and unique phytochemical profile study was carried out. In the screening analysis, a total of 121 shared compounds were characterized in FgAG and WsAG, respectively. The results showed that both of these two kinds of American ginseng were rich in natural components, and were similar in terms of the kinds of compound they contained. Furthermore, in non-targeted metabolomic analysis, when taking the contents of the constituents into account, it was found that there indeed existed quite a difference between FgAG and WsAG, and 22 robust known biomarkers enabling the differentiation were discovered. For WsAG, there were 12 potential biomarkers including two ocotillol-type saponins, two steroids, six damarane-type saponins, one oleanane-type saponins and one other compound. On the other hand, for FgAG, there were 10 potential biomarkers including two organic acids, six damarane-type saponins, one oleanane-type saponin, and one ursane. In a word, this study illustrated the similarities and differences between FgAG and WsAG, and provides a basis for explaining the effect of different growth environments on secondary metabolites.

Indexed as

BiomarkersDiscriminant AnalysisLeast-Squares AnalysisMetabolomicsMethanolPanaxPlant ExtractsPrincipal Component AnalysisBiomarkersMethanolPlant Extractsfield-grown American ginsengmetabolomic analysisscreening analysiswild-simulated American ginseng

Identifiers

PMID30889792
PMCPMC6470646

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.