ArticleEndocrine connections2019
Association between isolated hypothyroxinaemia in early pregnancy and perinatal outcomes.
Article in Endocrine connections, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Obstetric and offspring outcomes in isolated maternal hypothyroxinaemia: a systematic review and meta-analysis.Journal of endocrinological investigation · 2023Pooled it
- Association of thyroid disorders with gestational diabetes mellitus: a meta-analysis.Endocrine · 2021Pooled it
- Effect of Levothyroxine on Pregnancy Outcomes in Pregnant Women With Hypothyroxinemia: An Interventional Study.Frontiers in endocrinology · 2022Trial
- Maternal obesity and the incidence of large-for-gestational-age newborns in isolated hypothyroxinemia pregnancies: a comparative cohort study.Reproductive biology and endocrinology : RB&E · 2025Article
- Association between isolated maternal hypothyroxinemia during the first trimester and adverse pregnancy outcomes in Southern Chinese women: a retrospective study of 7051 cases.BMC pregnancy and childbirth · 2022Article
- What Iodine Intervention Measures Should Be Taken in Different Water Iodine Areas? Evidence from a Cross-sectional Chinese Survey.Biological trace element research · 2022Article
- Potential Risk Factors for Isolated Hypothyroxinemia in Women of Childbearing Age-Results from Retrospective Analysis.Journal of clinical medicine · 2021Article
- The association between COVID-19 pandemic and maternal isolated hypothyroxinemia in first and second trimesters.Psychoneuroendocrinology · 2021Article
- Associations of Hypothyroxinemia With Risk of Preeclampsia-Eclampsia and Gestational Hypertension.Frontiers in endocrinology · 2021Article
- Correlation between exposure to fine particulate matter and hypertensive disorders of pregnancy in Shanghai, China.Environmental health : a global access science source · 2020Article
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Authors and funding
6 authors.
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Abstract
backgroundThe effect of isolated maternal hypothyroxinaemia (IMH) on pregnancy complications and neonatal outcomes in human beings is still controversial.
methodsThis was a retrospective cohort study based on the electronic medical register system. The records of women with a singleton pregnancy who sought antenatal examination between January 2014 and December 2015 at Shanghai First Maternity and Infant Hospital were extracted from the electronic medical records system. Thyroid-stimulating hormone (TSH), free thyroxine (fT4) and anti-thyroperoxidase autoantibody (TPO-Ab) was measured before 20 gestational weeks, and a multiple logistic regression model was used to estimate the odds ratios of pregnancy complications and neonatal outcomes between euthyroid women and those with isolated hypothyroxinaemia.
resultsA total of 8173 women were included in this study, of whom 342 (4.18%) were diagnosed with IMH. Regression analysis showed that IMH diagnosed in the second trimester (13-20 weeks) was associated with an increased risk of hypertensive disorders of pregnancy (OR = 2.66, 95% CI: 1.38-5.10) and placenta abruption (OR = 3.64, 95% CI: 1.07-12.41), but not with preterm delivery (OR = 1.09, 95% CI: 0.50-2.40), small or large gestational age of infant (OR = 0.91, 95% CI: 0.39-2.12; OR = 1.16, 95% CI: 0.72-1.86), macrosomia (OR = 1.71, 95% CI: 0.95-3.07), gestational diabetes mellitus (OR = 1.36, 95% CI: 0.86-2.15) and placenta previa (OR = 1.62, 95% CI: 0.39-7.37).
conclusionIMH could be a risk factor for hypertensive disorders of pregnancy.
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