Evidence map›Paper›PMID 30889543›Full record

ArticleEnvironmental toxicology and pharmacology2019

Acute exposure to 4-OH-A, not PCB

Cassie J Gould, Colin J Saldanha, Victoria P Connaughton

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental toxicology and pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Cassie J GouldDepartment of Biology, American University, Washington, DC, United States; Behavior, Cognition & Neuroscience Program, American University, Washington, DC, United States; Center for Behavioral Neuroscience, American University, Washington, DC, United States. Electronic address: cg3794a@student.american.edu.
Colin J SaldanhaDepartment of Biology, American University, Washington, DC, United States; Behavior, Cognition & Neuroscience Program, American University, Washington, DC, United States; Center for Behavioral Neuroscience, American University, Washington, DC, United States.
Victoria P ConnaughtonDepartment of Biology, American University, Washington, DC, United States; Behavior, Cognition & Neuroscience Program, American University, Washington, DC, United States; Center for Behavioral Neuroscience, American University, Washington, DC, United States.
American University · US

Funding

Synaptic Aromatase;a Novel Form of Estrogen DeliveryR01NS042767 · NINDS · LEHIGH UNIVERSITY · PI SALDANHA, COLIN J · 2002 to 2012
$2.9M
Neural estrogen synthesis by astrocytic aromatization, and neuroinflammation.R21NS080585 · NINDS · AMERICAN UNIVERSITY · PI SALDANHA, COLIN J · 2012 to 2013
$384k
NINDS NIH HHS R01 NS042767NINDS NIH HHS R21 NS080585
6 · The paper itself

Abstract

Acute developmental exposure to pharmaceuticals or environmental contaminants can have deleterious, long lasting effects. Many of these compounds are endocrine disruptors (EDCs) that target estrogen signaling, with effects on reproductive and non-reproductive tissues. We recently reported that zebrafish larvae transiently exposed to the pharmaceutical EDC 4-OH-A display visual deficits as adults. Here, we examine whether these long-term effects are due to compound-induced morphological and/or cellular changes. Zebrafish aged 24 h, 48 h, 72 h, or 7 days post-fertilization (larvae) or 3-4mos (adults) were exposed to either 4-OH-A or PCB

Indexed as

ZebrafishAndrostenedioneAnimalsAromataseAromatase InhibitorsBrainChlorodiphenyl (54% Chlorine)Endocrine DisruptorsLarvaAndrostenedioneAromataseAromatase InhibitorsChlorodiphenyl (54% Chlorine)Endocrine DisruptorsformestaneAroclor1254DevelopmentEDCsEndocrine disruptorsEstradiolFormestane

Identifiers

PMID30889543
PMCPMC6516860
OpenAlexW2922249576

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.