ArticleInternational journal for parasitology. Drugs and drug resistance2019
Resistance formation to nitro drugs in Giardia lamblia: No common markers identified by comparative proteomics.
Article in International journal for parasitology. Drugs and drug resistance, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- In-silico, in-vitro, and proteomics analyses on repurposed drugs in targeting the small GTPase, Rho subfamily protein (Rho GTPase), and putative Rho GTPase-activating protein (RhoGAP) of Giardia lamblia.Journal, genetic engineering & biotechnology · 2025Article
- Transient Adaptation ofInternational journal of molecular sciences · 2024Article
- Comprehensive analysis of flavohemoprotein copy number variation in Giardia intestinalis: exploring links to metronidazole resistance.Parasites & vectors · 2024Article
- Investigating Antiprotozoal Chemotherapies with Novel Proteomic Tools-Chances and Limitations: A Critical Review.International journal of molecular sciences · 2024Review
- Assessment of Drug Activities againstPathogens (Basel, Switzerland) · 2024Article
- Article
- Development of New PCR Protocols to Detect Genetic Diversity in the Metronidazole Metabolism Genes in Susceptible and Refractory Clinical Samples of Giardia duodenalis.Acta parasitologica · 2024Article
- Comparative Proteomic Analysis ofInternational journal of molecular sciences · 2023Article
- Multilocus genotyping of Giardia duodenalis in pre-weaned calves with diarrhea in the Republic of Korea.PloS one · 2023Article
- Application of Proteomics to the Study of the Therapeutics and Pathogenicity ofDiagnostics (Basel, Switzerland) · 2022Review
- Characterization of Metronidazole-ResistantFrontiers in microbiology · 2022Article
- MDR1 protein (ABC-C1) Over Expression in Giardia Intestinalis Incubated with Albendazole and Nitazoxanide.Acta parasitologica · 2021Article
- Nitroreductase Activites inPathogens (Basel, Switzerland) · 2021Article
- Comparative proteomics of threeParasitology · 2020Article
- Antibacterial Discovery: 21st Century Challenges.Antibiotics (Basel, Switzerland) · 2020Article
- Metronidazole and Secnidazole Carbamates: Synthesis, Antiprotozoal Activity, and Molecular Dynamics Studies.Molecules (Basel, Switzerland) · 2020Article
- Metabolomic Profiling of Wildtype and TransgenicMetabolites · 2020Article
- Transfection With Plasmid Causing Stable Expression of a Foreign Gene Affects General Proteome Pattern inFrontiers in cellular and infection microbiology · 2020Article
- Genetic Diversity of the Flavohemoprotein Gene ofInfection and drug resistance · 2020Article
- In vitro-induction of metronidazole-resistant Giardia duodenalis is not associated with nucleotide alterations in the genes involved in pro-drug activation.Memorias do Instituto Oswaldo Cruz · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to elucidate the question whether resistance to nitro drugs in G. lamblia is due to common resistance markers, trophozoites of three resistant G. lamblia strains, namely C4, 1062ID10, and 713M3 were grown in the presence of the two nitro drugs metronidazole and nitazoxanide and compared to their corresponding wild-types WBC6, 106, and 713 by mass spectometry shotgun analysis of their proteomes. Depending on the strain and the nitro drug, more than 200 to 500 differentially expressed proteins were identified, but there were no common patterns across strains and drugs. All resistant strains underwent antigenic variation with distinct surface antigens like variant surface proteins or cysteine rich proteins depending on strain and nitro compound. A closer look on enzymes involved in nitroreduction and detoxification of nitro radicals, NO or O
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