Evidence map›Paper›PMID 30889380›Full record

ArticleCancer cell2019

Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways.

Christopher D Steele, Maxime Tarabichi, Dahmane Oukrif, Amy P Webster, Hongtao Ye, Matthew Fittall, Patrick Lombard, Iñigo Martincorena, Patrick S Tarpey, Grace Collord and 15 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 128 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Mutational signatures in hematological malignancies.Einstein (Sao Paulo, Brazil) · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 9 institutions in 3 countries.

Christopher D SteeleResearch Department of Pathology, Cancer Institute, University College London, London WC1E 6BT, UK.
Maxime TarabichiCancer Genomics Laboratory, The Francis Crick Institute, London NW1 1BF, UK.
Dahmane OukrifResearch Department of Pathology, Cancer Institute, University College London, London WC1E 6BT, UK.
Amy P WebsterDepartment of Cancer Biology, UCL Cancer Institute, University College London, London, UK.
Hongtao YeDepartment of Cellular and Molecular Pathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex HA7 4LP, UK.
Matthew FittallCancer Genomics Laboratory, The Francis Crick Institute, London NW1 1BF, UK.
Patrick LombardResearch Department of Pathology, Cancer Institute, University College London, London WC1E 6BT, UK.
Iñigo MartincorenaCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.
Patrick S TarpeyCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.
Grace CollordCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.
Kerstin HaaseCancer Genomics Laboratory, The Francis Crick Institute, London NW1 1BF, UK.
Sandra J StraussResearch Department of Pathology, Cancer Institute, University College London, London WC1E 6BT, UK; Department of Oncology, University College London Hospital NHS Foundation Trust, London, NW1 2PG, UK.
Fitim BerishaDepartment of Cellular and Molecular Pathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex HA7 4LP, UK.
Heli VaikkinenGenomics and Genome Engineering Core Facility, CRUK-UCL Centre, Cancer Institute, University College London, London WC1E 6BT, UK; Research Department of Oncology, Cancer Institute, University College London, London WC1E 6BT, UK.
Pawan DhamiGenomics and Genome Engineering Core Facility, CRUK-UCL Centre, Cancer Institute, University College London, London WC1E 6BT, UK.
Marnix JansenResearch Department of Pathology, Cancer Institute, University College London, London WC1E 6BT, UK; Department of Cellular Pathology, University College London Hospital NHS Foundation Trust, London NW1 2BU, UK.
Sam BehjatiCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.
M Fernanda AmaryDepartment of Cellular and Molecular Pathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex HA7 4LP, UK.
Roberto TiraboscoDepartment of Cellular and Molecular Pathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex HA7 4LP, UK.
Andrew FeberDepartment of Targeted Intervention, Division of Surgery and Interventional Science, University College London, London WC1E 6BT, UK.
Peter J CampbellCancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK; Department of Haematology, University of Cambridge, Hills Road, Cambridge CB2 2XY, UK.
Ludmil B AlexandrovDepartment of Cellular and Molecular Medicine, University of California, San Diego 92093, USA.
Peter Van LooCancer Genomics Laboratory, The Francis Crick Institute, London NW1 1BF, UK; Department of Human Genetics, University of Leuven, 3000 Leuven, Belgium.
Adrienne M FlanaganResearch Department of Pathology, Cancer Institute, University College London, London WC1E 6BT, UK; Department of Cellular and Molecular Pathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex HA7 4LP, UK.
Nischalan PillayResearch Department of Pathology, Cancer Institute, University College London, London WC1E 6BT, UK; Department of Cellular and Molecular Pathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex HA7 4LP, UK. Electronic address: n.pillay@ucl.ac.uk.
University College London · GBRoyal National Orthopaedic Hospital NHS Trust · GBWellcome Sanger Institute · GBGenomics (United Kingdom) · GBThe Francis Crick Institute · GBCRUK Lung Cancer Centre of Excellence · GBUniversity College London Hospitals NHS Foundation Trust · GBUniversity of California, San Diego · USUniversity of Cambridge · GB

Funding

Biotechnology and Biological Sciences Research Council BB/R009295/1Cancer Research UK 18387Cancer Research UK 21777Cancer Research UK FC001202Department of HealthMedical Research Council MR/M025411/1Wellcome Trust FC001202
6 · The paper itself

Abstract

Undifferentiated sarcomas (USARCs) of adults are diverse, rare, and aggressive soft tissue cancers. Recent sequencing efforts have confirmed that USARCs exhibit one of the highest burdens of structural aberrations across human cancer. Here, we sought to unravel the molecular basis of the structural complexity in USARCs by integrating DNA sequencing, ploidy analysis, gene expression, and methylation profiling. We identified whole genome duplication as a prevalent and pernicious force in USARC tumorigenesis. Using mathematical deconvolution strategies to unravel the complex copy-number profiles and mutational timing models we infer distinct evolutionary pathways of these rare cancers. In addition, 15% of tumors exhibited raised mutational burdens that correlated with gene expression signatures of immune infiltration, and good prognosis.

Indexed as

DNA MethylationEvolution, MolecularGene DuplicationGene Expression ProfilingHumansMutationPloidiesPrognosisSarcomaSequence Analysis, DNAcancer evolutioncopy-number signaturesgenomicsimmuno-oncologymutational signaturessarcomatumor mutational burden

Identifiers

PMID30889380
PMCPMC6428691
OpenAlexW2905546391

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.