ArticleJournal of periodontology2019
Acceleration of bone regeneration of horizontal bone defect in rats using collagen-binding basic fibroblast growth factor combined with collagen scaffolds.
Article in Journal of periodontology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- CH02 peptide-stimulated periodontal ligament cells enhance periodontal defect repair in rats.BMC oral health · 2025Article
- Histologic evidence of the effect of fibroblast growth factor 2 on periodontal regeneration: A scoping review of animal studies.Journal of advanced periodontology & implant dentistry · 2025Review
- Effect of a Recombinant Human Basic Fibroblast Growth Factor 2 (rhFGF-2)-Impregnated Atelocollagen Sponge on Vertical Guided Bone Regeneration in a Rat Calvarial Model.Dentistry journal · 2025Article
- Enhancing Bone Formation Through bFGF-Loaded Mesenchymal Stromal Cell Spheroids During Fracture Healing in Mice.Bioengineering (Basel, Switzerland) · 2024Article
- Supra-Alveolar Bone Regeneration: Progress, Challenges, and Future Perspectives.Composites. Part B, Engineering · 2024Article
- Assessment and comparative study of diosgenin doses in alleviating experimental periodontitis.BMC oral health · 2024Article
- Mussel-inspired electroactive, antibacterial and antioxidative composite membranes with incorporation of gold nanoparticles and antibacterial peptides for enhancing skin wound healing.Journal of biological engineering · 2024Article
- 3D-printed PCL@BG scaffold integrated with SDF-1α-loaded hydrogel for enhancing local treatment of bone defects.Journal of biological engineering · 2024Article
- Preparation of Collagen/Hydroxyapatite Composites Using the Alternate Immersion Method and Evaluation of the Cranial Bone-Forming Capability of Composites Complexed with Acidic Gelatin and b-FGF.Materials (Basel, Switzerland) · 2022Article
- Regulatory perspectives of combination products.Bioactive materials · 2022Review
- Synthetic materials in craniofacial regenerative medicine: A comprehensive overview.Frontiers in bioengineering and biotechnology · 2022Review
- Analysis of the Correlation of Basic Fibroblast Growth Factor in Serum of Patients with Diffuse Large B-Cell Lymphoma with Clinicopathological Efficacy and International Prognostic Index.Contrast media & molecular imaging · 2022Article
- The recent advances in scaffolds for integrated periodontal regeneration.Bioactive materials · 2021Review
- Real-time assessment of guided bone regeneration in critical size mandibular bone defects in rats using collagen membranes with adjunct fibroblast growth factor-2.Journal of dental sciences · 2021Article
- Periodontal Ligament Cell Sheets and RGD-Modified Chitosan Improved Regeneration in the Horizontal Periodontal Defect Model.European journal of dentistry · 2020Article
- Utility of Air Bladder-Derived Nanostructured ECM for Tissue Regeneration.Frontiers in bioengineering and biotechnology · 2020Article
- Acceleration of bone regeneration of horizontal bone defect in rats using collagen-binding basic fibroblast growth factor combined with collagen scaffolds.Journal of periodontology · 2019Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBasic fibroblast growth factor (bFGF) has been applied for periodontal regeneration. However, the application depends on bone defect morphology because bFGF diffuses rapidly from defect sites. In a previous study, collagen-binding bFGF (CB-bFGF) has been shown to enhance bone formation by collagen-anchoring in the orthopedic field. The aim of this study is to demonstrate the efficacy of CB-bFGF with collagen scaffolds in bone regeneration of horizontal bone defect.
methodsCell proliferation activity and collagen binding activity of CB-bFGF was confirmed by WST-8 assay and collagen binding assay, respectively. The retention of CB-bFGF in the collagen sheet (CS) was measured by fluorescence imaging. The rat horizontal alveolar bone defect model was employed to investigate the efficacy of CB-bFGF with collagen powder (CP). After 4 and 8 weeks, the regenerative efficacy was evaluated by microcomputed tomography, histological, and immunohistochemical analyses.
resultsCB-bFGF had a comparable proliferation activity to bFGF and a collagen binding activity. CB-bFGF was retained in CS longer than bFGF. At 8 weeks postoperation, bone volume, bone mineral content, and new bone area in CB-bFGF/CP group were significantly increased compared with those in other groups. Furthermore, epithelial downgrowth was significantly suppressed in CB-bFGF/CP group. At 4 weeks, the numbers of osteocalcin, proliferating cell nuclear antigen, and osteopontin-positive cells at the regeneration site in CB-bFGF/CP group were greater than those in other groups.
conclusionsCB-bFGF/CP effectively promoted bone regeneration of horizontal bone defect possibly by sustained release of bFGF. The potential of CB-bFGF composite material for improved periodontal regeneration in vertical axis was shown.
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