ReviewEpilepsia2019
Neuroimaging and connectomics of drug-resistant epilepsy at multiple scales: From focal lesions to macroscale networks.
Review in Epilepsia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 116 citations in OpenAlex.
- Network reorganization of anterograde thalamic connectivity during non-periodic patterned deep brain stimulation.iScience · 2026Article
- Rethinking cortical hypertrophy in temporal lobe epilepsy.Brain : a journal of neurology · 2026Review
- Ventral anterior thalamic dysfunction distinguishes seizure generalization in temporal lobe epilepsy.Epilepsia · 2026Article
- Etiology-specific trajectories of longitudinal functional connectivity and network topology in posttraumatic and mesial temporal lobe epileptogenesis.Experimental neurology · 2026Article
- Advancing the Paradigm of Temporal Lobe Epilepsy as a Network Disease: The Promise of Biomarkers and Targeted Disease Modification.International journal of molecular sciences · 2026Review
- The onco-functional reorganization of language network underlying metaplasticity induced by gliomas.Frontiers in oncology · 2026Article
- Transcriptomic decoding of regional cortical vulnerability to drug-resistant epilepsy using 7T MRI.Communications biology · 2025Article
- Multimodal quantitative analysis guides precise preoperative localization of epilepsy.Journal of neurology · 2025Review
- Individualized morphological covariation network aberrance associated with seizure relapse after antiseizure medication withdrawal.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- The Role of Neuroinflammation and Network Anomalies in Drug-Resistant Epilepsy.Neuroscience bulletin · 2025Review
- Anticonvulsant Potential and Toxicological Profile ofPlants (Basel, Switzerland) · 2025Article
- Brain local structural connectomes and the subtypes of the medial temporal lobe parcellations.Frontiers in neuroscience · 2025Article
- Multilayer network analysis across cortical depths in 7-T resting-state fMRI.Network neuroscience (Cambridge, Mass.) · 2025Article
- Multilayer Network Analysis across Cortical Depths in Resting-State 7T fMRI.bioRxiv : the preprint server for biology · 2024Article
- Connectome reorganization associated with temporal lobe pathology and its surgical resection.Brain : a journal of neurology · 2024Article
- Edge-wise analysis reveals white matter connectivity associated with focal to bilateral tonic-clonic seizures.Epilepsia · 2024Article
- A WORLDWIDE ENIGMA STUDY ON EPILEPSY-RELATED GRAY AND WHITE MATTER COMPROMISE ACROSS THE ADULT LIFESPAN.bioRxiv : the preprint server for biology · 2024Article
- Association between structural brain MRI abnormalities and epilepsy in older adults.Annals of clinical and translational neurology · 2024Article
- Neurobehavioral and Clinical Comorbidities in Epilepsy: The Role of White Matter Network Disruption.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Connectome-Based Neurosurgery in Primary Intra-Axial Neoplasms: Beyond the Traditional Modular Conception of Brain Architecture for the Preservation of Major Neurological Domains and Higher-Order Cognitive Functions.Life (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
Abstract
Epilepsy is among the most common chronic neurologic disorders, with 30%-40% of patients having seizures despite antiepileptic drug treatment. The advent of brain imaging and network analyses has greatly improved the understanding of this condition. In particular, developments in magnetic resonance imaging (MRI) have provided measures for the noninvasive characterization and detection of lesions causing epilepsy. MRI techniques can probe structural and functional connectivity, and network analyses have shaped our understanding of whole-brain anomalies associated with focal epilepsies. This review considers the progress made by neuroimaging and connectomics in the study of drug-resistant epilepsies due to focal substrates, particularly temporal lobe epilepsy related to mesiotemporal sclerosis and extratemporal lobe epilepsies associated with malformations of cortical development. In these disorders, there is evidence of widespread disturbances of structural and functional connectivity that may contribute to the clinical and cognitive prognosis of individual patients. It is hoped that studying the interplay between macroscale network anomalies and lesional profiles will improve our understanding of focal epilepsies and assist treatment choices.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.