Trial reportPloS one2019
Identification of the microbial diversity after fecal microbiota transplantation therapy for chronic intractable constipation using 16s rRNA amplicon sequencing.
Trial report in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 41 citations in OpenAlex.
- Gut microbiota dysbiosis and amino acid metabolic dysregulation in children with allergic rhinitis complicated by constipation.Microbiology spectrum · 2026Article
- Fecal Microbiota Transplantation for Disorders of Gut-Brain Interaction: Current Insights, Effectiveness, and Future Perspectives.Current gastroenterology reports · 2025Review
- Melatonin as a Mediator of the Gut Microbiota-Host Interaction: Implications for Health and Disease.Antioxidants (Basel, Switzerland) · 2023Review
- Revisiting the Intestinal Microbiome and Its Role in Diarrhea and Constipation.Microorganisms · 2023Review
- Sheep fecal transplantation affects growth performance in mouse models by altering gut microbiota.Journal of animal science · 2022Article
- Fecal Microbiota Transplantation as New Therapeutic Avenue for Human Diseases.Journal of clinical medicine · 2022Review
- Gut microbiota alternation under the intestinal epithelium-specific knockout of mouse Piga gene.Scientific reports · 2022Article
- Adverse events of intestinal microbiota transplantation in randomized controlled trials: a systematic review and meta-analysis.Gut pathogens · 2022Review
- Dietary inflammatory index and its relationship with gut microbiota in individuals with intestinal constipation: a cross-sectional study.European journal of nutrition · 2022Article
- Development of soil-less substrates capable of degrading organic nitrogen into nitrate as in natural soils.Scientific reports · 2022Article
- KOMB: K-core based de novo characterization of copy number variation in microbiomes.Computational and structural biotechnology journal · 2022Article
- Analyses of publicly availableVirulence · 2021Article
- The mechanism of intestinal flora dysregulation mediated by intestinal bacterial biofilm to induce constipation.Bioengineered · 2021Article
- Intestinal Inflammation and Parkinson's Disease.Aging and disease · 2021Review
- Article
- Predicting the Role of the Human Gut Microbiome in Constipation Using Machine-Learning Methods: A Meta-Analysis.Microorganisms · 2021Article
- Evaluation of fecal microbiota transplantation in Parkinson's disease patients with constipation.Microbial cell factories · 2021Article
- Prebiotics/Probiotics Mixture Induced Changes in Cecal Microbiome and Intestinal Morphology Alleviated the Loperamide-Induced Constipation in Rat.Food science of animal resources · 2021Article
- Current Overview on Clinical Management of Chronic Constipation.Journal of clinical medicine · 2021Review
- The Efficacy and Safety of Fecal Microbiota Transplantation Combined With Biofeedback for Mixed Constipation: A Retrospective Cohort Study.Frontiers in medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFecal microbiota transplantation (FMT) is an effective therapeutic approach for the treatment of functional gastrointestinal disease by restoring gut microbiota; however, there is a lack of sufficient understanding regarding which microbial populations successfully colonize the recipient gut. This study characterized microbial composition and diversity in patients diagnosed with chronic constipation at 1 month and 1 year after FMT.
methodsWe explored the microbial diversity of pre- and posttransplant stool specimens from patients using 16S rRNA gene sequencing, followed by functional analysis.
resultsThe results identified 22 species of microorganisms colonized in the recipients from the donors at 1 month after FMT. One-year follow-up of the patient identified the colonization of 18 species of microorganisms, resulting in identification of species in significant abundance, including Bacteroides fragilis and Hungatella hathewayi in the recipient at 1 month after FMT and Dialister succinatiphilus, Coprococcus catus, and Sutterella stercoricanis at 1 year after FMT. The majority of the colonized species belong to the phylum Firmicutes and carry genes related to polysaccharide metabolism and that enhance the energy-harvesting efficiency of the host.
conclusionThese results suggest that FMT is effective for the treatment of chronic constipation through the restoration and colonization of donor microbiota in the recipient gut up to 1 year after FMT.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.