Evidence map›Paper›PMID 30889199›Full record

ArticlePloS one2019

7T MRI in epilepsy patients with previously normal clinical MRI exams compared against healthy controls.

Rebecca Emily Feldman, Bradley Neil Delman, Puneet Singh Pawha, Hadrien Dyvorne, John Watson Rutland, Jiyeoun Yoo, Madeline Cara Fields, Lara Vanessa Marcuse, Priti Balchandani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  20. Classifying epilepsy pragmatically: Past, present, and future.Journal of the neurological sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rebecca Emily FeldmanTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.ORCID 0000-0001-8403-9807
Bradley Neil DelmanRadiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Puneet Singh PawhaRadiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Hadrien DyvorneTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
John Watson RutlandTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Jiyeoun YooDepartment of Neurology, Mount Sinai Hospital, New York, New York, United States of America.
Madeline Cara FieldsDepartment of Neurology, Mount Sinai Hospital, New York, New York, United States of America.
Lara Vanessa MarcuseDepartment of Neurology, Mount Sinai Hospital, New York, New York, United States of America.
Priti BalchandaniTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

Funding

High Resolution Magnetic Resonance Imaging and Spectroscopy of Epilepsy at 7TR00NS070821 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BALCHANDANI, PRITI · 2013 to 2015
$734k
NINDS NIH HHS R00 NS070821
6 · The paper itself

Abstract

objectiveTo compare by 7 Tesla (7T) magnetic resonance imaging (MRI) in patients with focal epilepsy who have non-lesional clinical MRI scans with healthy controls.

methods37 patients with focal epilepsy, based on clinical and electroencephalogram (EEG) data, with non-lesional MRIs at clinical field strengths and 21 healthy controls were recruited for the 7T imaging study. The MRI protocol consisted of high resolution T1-weighted, T2-weighted and susceptibility weighted imaging sequences of the entire cortex. The images were read by two neuroradiologists, who were initially blind to clinical data, and then reviewed a second time with knowledge of the seizure onset zone.

resultsA total of 25 patients had findings with epileptogenic potential. In five patients these were definitely related to their epilepsy, confirmed through surgical intervention, in three they co-localized to the suspected seizure onset zone and likely caused the seizures. In seven patients the imaging findings co-localized to the suspected seizure onset zone but were not the definitive cause, and ten had cortical lesions with epileptogenic potential that did not localize to the suspected seizure onset zone. There were multiple other findings of uncertain significance found in both epilepsy patients and healthy controls. The susceptibility weighted imaging sequence was instrumental in guiding more targeted inspection of the other structural images and aiding in the identification of cortical lesions. SIGNIFICANCE: Information revealed by the improved resolution and enhanced contrast provided by 7T imaging is valuable in noninvasive identification of lesions in epilepsy patients who are non-lesional at clinical field strengths.

Indexed as

Magnetic Resonance ImagingAdolescentAdultAgedCase-Control StudiesEpilepsies, PartialFemaleHippocampusHumansMaleMiddle AgedNeuroimagingObserver VariationRadiologyRetrospective StudiesSeizures

Identifiers

PMID30889199
PMCPMC6424456

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.