ArticleJournal of pediatric gastroenterology and nutrition2019
Normal Liver Stiffness Values in Children: A Comparison of Three Different Elastography Methods.
Article in Journal of pediatric gastroenterology and nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- KASL clinical practice guidelines for noninvasive tests to assess liver fibrosis in chronic liver disease.Clinical and molecular hepatology · 2024Guideline
- Biomarkers for liver disease in urea cycle disorders.Molecular genetics and metabolism · 2021Trial
- Normal liver stiffness values measured with MR elastography and two-dimensional shear wave elastography in children aged 9-17 years.Abdominal radiology (New York) · 2026Article
- Reference values for shear wave elastography, shear wave dispersion and attenuation imaging in healthy paediatric livers.Pediatric radiology · 2026Article
- Pediatric MASLD in Severe Obesity: Current Clinical Perspectives on Diagnosis and Treatment.Journal of clinical medicine · 2025Review
- Changes in Liver Shear Wave Elastography of Preterm Infants during Hospitalization.American journal of perinatology · 2025Article
- Reference Range of Quantitative MRI Metrics Corrected T1 and Liver Fat Content in Children and Young Adults: Pooled Participant Analysis.Children (Basel, Switzerland) · 2024Article
- Weight-specific normal liver stiffness values in children.Pediatric radiology · 2024Article
- Cystic fibrosis hepatobiliary involvement: an update on imaging in diagnosis and monitoring.Pediatric radiology · 2024Review
- Article
- Liver and kidney ultrasound elastography in children and young adults with hypertension or chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2023Article
- Ultrasound Elastography in Children.Children (Basel, Switzerland) · 2023Review
- Liver transient elastography values in healthy South African children.BMC pediatrics · 2023Article
- Accuracy Rate of Shear Wave Elastography in Detecting the Liver Fibrosis in Overweight and Obese Children with Hepatosteatosis.Turkish archives of pediatrics · 2023Article
- Usefulness of two-dimensional shear wave elastography in the assessment of non-alcoholic fatty liver disease in children and adolescents.Scientific reports · 2023Article
- Liver fibrosis in children: a comprehensive review of mechanisms, diagnosis, and therapy.Clinical and experimental pediatrics · 2023Article
- Validation of attenuation imaging coefficient, shear wave elastography, and dispersion as emerging tools for non-invasive evaluation of liver tissue in children.Frontiers in pediatrics · 2023Article
- FIB-4 and APRI scores for progressive liver fibrosis diagnosis in children with biliary atresia.Frontiers in pediatrics · 2023Article
- Ultrasound elastography in children - nice to have for scientific studies or arrived in clinical routine?Molecular and cellular pediatrics · 2022Review
- Prospective assessment of liver stiffness by shear wave elastography in childhood obesity: a pilot study.Endocrine · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesNoninvasive tests for the evaluation of liver fibrosis are particularly helpful in children to avoid general anesthesia and potential complications of invasive tests. We aimed to establish reference values for 2 different elastography methods in a head-to-head comparison for children and adolescents 4 to 17 years, using transient elastography as common reference in a subset.
methodsA total of 243 healthy participants aged 4 to 17 years were examined by a single observer with a full liver B-mode scan before elastography, following a minimum of 3 hours fasting. Liver stiffness measurements (LSMs) using 2-dimensional shear wave elastography (2D-SWE, GE Logiq E9) and point shear wave elastography (pSWE, Samsung RS80A with Prestige) were performed in all participants, and compared to transient elastography (TE, FibroScan) in a subset (n = 87). Interobserver agreement was evaluated in 50 children aged 4 to 17 years.
resultsValid measurements were obtained in 242 of 243 (99.6%) subjects for 2D-SWE, 238 of 243 (97.9%) for pSWE, and in 83 of 87 (95.4%) for TE. Median liver stiffness overall was 3.3 (interquartile range [IQR] 2.7-4.3), 4.1 (IQR 3.6-4.7), and 4.1 kPa (IQR 3.5-4.6) for 2D-SWE, pSWE, and TE, respectively. Intraclass correlation coefficients between observers were 0.84 and 0.83 for 2D-SWE and pSWE, respectively. LSM values were significantly lower for 2D-SWE compared to pSWE and TE, and increased with advancing age. Higher LSM values in males were observed in adolescents.
conclusionsAll methods showed excellent feasibility. 2D-SWE showed significantly lower LSM values than pSWE and TE, and lower failure rate compared to TE. Our results further indicate an age and sex effect on LSM values.
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