Evidence map›Paper›PMID 30889048›Full record

ReviewJournal of hypertension2019

Effects of isometric resistance training on resting blood pressure: individual participant data meta-analysis.

Neil A Smart, Damien Way, Debra Carlson, Philip Millar, Cheri McGowan, Ian Swaine, Anthony Baross, Reuben Howden, Raphael Ritti-Dias, Jim Wiles and 4 more

2 registry-linked trialsOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 47 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 9 pooled it
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07251920 phase3completednot on this mapstarted 2024, after this paper: background citation

Examination of the Dose-dependent Effects of Isometric Resistance Training on Decreases in Blood Pressure in Pre- and Hypertensive Adults

TypeinterventionalSponsorThe University of NorthamptonRan2024 to 2024Enrolled30ConditionsHypertension, Blood Pressure, HighArmsIsometric resistance training
NCT07665034 narecruitingnot on this mapstarted 2025, after this paper: background citation

The Impact of Isometric Resistance Exercise on Accelerated Atherosclerosis in Hypertension: A Study of Randomized Controlled Trial

TypeinterventionalSponsorChinese University of Hong KongRan2025 to 2027Enrolled200ConditionsAtherosclerosis Cardiovascular DiseaseArmsSquatting Exercise, Stretching (Yoga) Exercise
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 9 syntheses or guidelines pooled it, 105 citations in OpenAlex.

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  7. Physical fitness training for stroke patients.The Cochrane database of systematic reviews · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 6 countries.

Neil A SmartSchool of Science and Technology, University of New England, Armidale, New South Wales, Australia.
Damien WaySchool of Science and Technology, University of New England, Armidale, New South Wales, Australia.
Debra CarlsonSchool of Science and Technology, University of New England, Armidale, New South Wales, Australia.
Philip MillarDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph.
Cheri McGowanDepartment of Kinesiology, University of Windsor, Windsor, Ontario, Canada.
Ian SwaineDepartment of Life and Sports Sciences, University of Greenwich.
Anthony BarossSport and Exercise Science, University of Northampton, UK.
Reuben HowdenDepartment of Kinesiology, University of North Carolina, at Charolotte, North Carolina, USA.
Raphael Ritti-DiasUniversidade Nove de Julho, Brazil.
Jim WilesSchool of Human and Life Sciences, Canterbury Christ Church University, UK.
Véronique CornelissenDepartment of Rehabilitation Sciences, KU Leuven, Leuven, Belgium.
Ben GordonDepartment of Exercise and Rehabilitative Sciences, Slippery Rock University, Slippery Rock, Philadelphia, USA.
Rod TaylorUniversity of Glasgow, UK.
Bea BleileSchool of Science and Technology, University of New England, Armidale, New South Wales, Australia.
University of New England · AUCanterbury Christ Church University · GBGTx (United States) · USKU Leuven · BESlippery Rock University · USUniversidade Nove de Julho · BRUniversity of Glasgow · GBUniversity of Greenwich · GBUniversity of Guelph · CAUniversity of Northampton · GBUniversity of Windsor · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious meta-analyses based on aggregate group-level data report antihypertensive effects of isometric resistance training (IRT). However, individual participant data meta-analyses provide more robust effect size estimates and permit examination of demographic and clinical variables on IRT effectiveness.

methodsWe conducted a systematic search and individual participant data (IPD) analysis, using both a one-step and two-step approach, of controlled trials investigating at least 3 weeks of IRT on resting systolic, diastolic and mean arterial blood pressure.

resultsAnonymized individual participant data were provided from 12 studies (14 intervention group comparisons) involving 326 participants (52.7% medicated for hypertension); 191 assigned to IRT and 135 controls, 25.2% of participants had diagnosed coronary artery disease. IRT intensity varied (8-30% MVC) and training duration ranged from 3 to 12 weeks. The IPD (one-step) meta-analysis showed a significant treatment effect for the exercise group participants experiencing a reduction in resting SBP of -6.22 mmHg (95% CI -7.75 to -4.68; P < 0.00001); DBP of -2.78 mmHg (95% CI -3.92 to -1.65; P = 0.002); and mean arterial blood pressure (MAP) of -4.12 mmHg (95% CI -5.39 to -2.85; P < 0.00001). The two-step approach yielded similar results for change in SBP -7.35 mmHg (-8.95 to -5.75; P < 0.00001), DBP MD -3.29 mmHg (95% CI -5.12 to -1.46; P = 0.0004) and MAP MD -4.63 mmHg (95% CI -6.18 to -3.09: P < 0.00001). Sub-analysis revealed that neither clinical, medication, nor demographic participant characteristics, or exercise program features, modified the IRT treatment effect.

conclusionThis individual patient analysis confirms a clinically meaningful and statistically significant effect of IRT on resting SBP, DBP and mean arterial blood pressure.

Indexed as

Blood PressureBlood Pressure DeterminationExerciseHumansHypertensionResistance TrainingRest

Identifiers

PMID30889048
PMCPMC6727950
OpenAlexW2924556947

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.