Evidence map›Paper›PMID 30889013›Full record

ArticleAIDS (London, England)2019

Short-term outcomes for lung cancer resection surgery in HIV infection.

Keith M Sigel, Kimberly Stone, Juan P Wisnivesky, Lesley S Park, Chung Yin Kong, Michael J Silverberg, Sheldon Brown, Matthew Goetz, Maria C Rodriguez-Barradas, Cynthia Gibert and 5 more

Open access · greenAbstract read
In one paragraph

Article in AIDS (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Cancer Treatment Disparities in People With HIV in the United States, 2001-2019.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Article
  5. Article
  6. HIV-associated lung disease.Nature reviews. Disease primers · 2023
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 1 country.

Keith M SigelIcahn School of Medicine at Mount Sinai, New York, New York.
Kimberly StoneIcahn School of Medicine at Mount Sinai, New York, New York.
Juan P WisniveskyIcahn School of Medicine at Mount Sinai, New York, New York.
Lesley S ParkStanford University School of Medicine, Palo Alto, California.
Chung Yin KongInstitute for Technology Assessment, Massachusetts General Hospital, Boston, Massachusetts.
Michael J SilverbergKaiser Permanente Northern California, Oakland, California.
Sheldon BrownIcahn School of Medicine at Mount Sinai, New York, New York.
Matthew GoetzVA Greater Los Angeles Healthcare System.
Maria C Rodriguez-BarradasMichael E. DeBakey VA Medical Center and Baylor University School of Medicine, Houston, Texas.
Cynthia GibertWashington DC VA Medical Center and George Washington University School of Medicine, Washington, District of Columbia.
Fatma SheblMassachussets General Hospital, Boston, Massachusetts.
Roger BedimoVA North Texas Healthcare Center and University of Texas Southwestern School of Medicine, Dallas, Texas.
Roxanne WadiaVA Connecticut Healthcare System, West Haven.
Joseph KingVA Connecticut Healthcare System, West Haven.
Kristina CrothersUniversity of Washington School of Medicine, Seattle, Washington, District of Columbia, USA.
Icahn School of Medicine at Mount Sinai · USMassachusetts General Hospital · USGeorge Washington University · USJames J. Peters VA Medical Center · USMichael E. DeBakey VA Medical Center · USStanford University · USUniversity of California, Los Angeles · USUniversity of Washington · USVA Connecticut Healthcare System · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Alcohol Associated Outcomes Among HIV+/-Aging VeteransU01AA013566 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2002 to 2005
$10.1M
Alcohol and Multisubstance Use in the Veterans Aging Cohort StudyU01AA020790 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$7.7M
Sex Disparities in Overall Response to ART Among HIV Infected IndividualsU24AA020794 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$5.5M
3/3 COMpAAAS Tripartite: ART-CC, KP, and VAU01AA026224 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2017 to 2021
$2.9M
Benefits and Harms of Lung Cancer Screening in HIV InfectionR01CA173754 · NCI · UNIVERSITY OF WASHINGTON · PI BRAITHWAITE, RONALD SCOTT, CROTHERS, KRISTINA ANNE · 2013 to 2017
$2.5M
Optimizing Lung Cancer Treatment in HIV Infected PersonsR01CA210806 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SIGEL, KEITH MAGNUS · 2017 to 2020
$2.3M
The Cost-Effectiveness of Lung Cancer Screening in HIV InfectionK07CA180782 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SIGEL, KEITH MAGNUS · 2014 to 2018
$646k
NCATS NIH HHS UL1 TR001863NCI NIH HHS K07 CA180782NCI NIH HHS R01 CA173754NCI NIH HHS R01 CA210806NIAAA NIH HHS U01 AA013566NIAAA NIH HHS U01 AA020790NIAAA NIH HHS U01 AA026224NIAAA NIH HHS U24 AA020794
6 · The paper itself

Abstract

objectiveLung cancer is the leading cause of cancer death in people living with HIV (PWH). Surgical resection is a key component of potentially curative treatment regimens for early-stage lung cancers, but its safety is unclear in the setting of HIV. From a national cohort, we assessed potential differences in the risk of major lung cancer surgery complications by HIV status.

designWe linked clinical and cancer data from the Veterans Aging Cohort Study (VACS) and Veterans Affairs Corporate Data Warehouse to outcomes from the Veterans Affairs Surgical Quality Improvement Program (VASQIP) and identified 8371 patients (137 PWH, 8234 uninfected) who underwent lung cancer surgeries between 2000 and 2016.

methodsWe compared rates of 15 major short-term surgical complications by HIV status.

resultsUse of surgical resection for early-stage lung cancer did not differ by HIV status. Lung cancer surgery postoperative (30-day) mortality was 2.0% for PWH and did not differ by HIV status (P = 0.9). Pneumonia was the most common complication for both PWH and uninfected veterans, but did not differ significantly in prevalence between groups (11.0% for PWH versus 9.4%; P = 0.5). The frequency of complications did not differ by HIV status for any complication (all P > 0.3). There were no significant predictors of postoperative complications for PWH.

conclusionsIn a national antiretroviral-era cohort of lung cancer patients undergoing surgical lung resection, short-term outcomes after surgery did not differ significantly by HIV status. Concerns regarding short-term surgical complications should have limited influence on treatment decisions for PWH with lung cancer.

Indexed as

AgedCohort StudiesFemaleHIV InfectionsHumansLung NeoplasmsMaleMiddle AgedSurvival AnalysisTreatment Outcome

Identifiers

PMID30889013
PMCPMC6565364
OpenAlexW2930466296

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.