ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019
Chronic gestational hypoxia accelerates ovarian aging and lowers ovarian reserve in next-generation adult rats.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Clinical evidence of growth hormone for infertile women with diminished ovarian reserve undergoing IVF: a systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- The impact of metformin on placental ageing in humans and mice.The Journal of physiology · 2025Trial
- Association of offspring's birth weight considering maternal parity with offspring's survival, productive and reproductive performance and AMH concentration from birth to the first lactation period.Tropical animal health and production · 2025Article
- Depletion ofInternational journal of molecular sciences · 2025Article
- A disturbed communication between hypothalamic-pituitary-ovary axis and gut microbiota in female infertility: is diet to blame?Journal of translational medicine · 2025Review
- Identification of hypoxia-related diagnostic biomarkers and immune signatures in diminished ovarian reserve.Frontiers in genetics · 2025Article
- Association of sleep disturbances with diminished ovarian reserve in women undergoing infertility treatment.Scientific reports · 2024Article
- Review
- Enhanced solute transport and steady mechanical stimulation in a novel dynamic perifusion bioreactor increase the efficiency of theFrontiers in bioengineering and biotechnology · 2024Article
- Gestational Intermittent Hypoxia Impairs ATJournal of biotechnology and biomedicine · 2024Article
- Article
- Facilitation of Ovarian Response by Mechanical Force-Latest Insight on Fertility Improvement in Women with Poor Ovarian Response or Primary Ovarian Insufficiency.International journal of molecular sciences · 2023Review
- Article
- Article
- Hypo-Hydroxymethylation of Nobox is Associated with Ovarian Dysfunction in Rat Offspring Exposed to Prenatal Hypoxia.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Rodent models in placental research. Implications for fetal origins of adult disease.Animal reproduction · 2022Article
- Clinical Efficacy of Assisted Reproductive Technology Combined with Progesterone Capsules in the Treatment of Infertility Caused by Diminished Ovarian Reserve and Its Influence on Serum FSH, EJournal of healthcare engineering · 2022Article
- Intraovarian vascular enhancement via stromal injection of platelet-derived growth factors: Exploring subsequent oocyte chromosomal status and in vitro fertilization outcomes.Clinical and experimental reproductive medicine · 2020Review
- Prenatal Hypoxia and Placental Oxidative Stress: Insights from Animal Models to Clinical Evidences.Antioxidants (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
Chronic fetal hypoxia is a common complication observed in human pregnancy, impacting pregnancies across global contexts. Exposure to chronic intrauterine hypoxia has major short- and long-term consequences for offspring health. However, the impact of chronic gestational hypoxia on female reproductive system development is unknown. We aimed to understand the impact of exposure to chronic fetal hypoxia on the developing female reproductive system. Wistar rat dams underwent normoxia (21%) or hypoxia (13%) during pregnancy. Postnatally, all female offspring were maintained in normoxic conditions into early adulthood. Female rats exposed to chronic gestational hypoxia (13%) during their intrauterine development had decreased ovarian primordial follicular reserve compared to controls (
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Registered trials
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