ArticleAmerican journal of respiratory and critical care medicine2019
Correlating Cystic Fibrosis Transmembrane Conductance Regulator Function with Clinical Features to Inform Precision Treatment of Cystic Fibrosis.
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Article in American journal of respiratory and critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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53citing papers in PubMed
10.1field-weighted citation impact, top 1% of its field
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 93 citations in OpenAlex.
- Elexacaftor/tezacaftor/ivacaftor in children aged ≥6 years with cystic fibrosis heterozygous forThe European respiratory journal · 2025Trial
- A Randomized, Double-Blind, Placebo-Controlled, Multiple Dose Escalation Study to Evaluate the Safety and Pharmacokinetics of ELX-02 in Healthy Subjects.Clinical pharmacology in drug development · 2021Trial
- Impact of CFTR modulator concentrations on clinical response in cystic fibrosis.The European respiratory journal · 2026Observational
- Functional Rescue of CFTR-Dependent Transport in a Pancreatic Ductal Epithelial Cell Model: The Impact of Pharmacological Modulation and Inflammation.International journal of molecular sciences · 2026Article
- Base editing and nanoparticle transfection of airway cell types essential for treatment of cystic fibrosis.JCI insight · 2026Article
- Base editing and nanoparticle transfection of airway cell types essential for treatment of cystic fibrosis.bioRxiv : the preprint server for biology · 2025Article
- A novel drug series optimized to address cystic fibrosis and other CFTR deficiency diseases of human airways.npj drug discovery · 2025Article
- CFTR Modulators Counteract F508del CFTR Functional Defects in a Pancreatic Epithelial Model of Cystic Fibrosis.Life (Basel, Switzerland) · 2025Article
- Genetic Heterogeneity Correlated with Phenotypic Variability in 48 Patients with Cystic Fibrosis.Journal of clinical medicine · 2025Article
- An engineered glutamic acid tRNA for efficient suppression of pathogenic nonsense mutations.Nucleic acids research · 2025Article
- Heterogeneity of CFTR modulator-induced sweat chloride concentrations in people with cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2024Article
- Racial inequities and rareJournal of clinical & translational endocrinology · 2024Article
- tRNA therapeutics for genetic diseases.Nature reviews. Drug discovery · 2024Review
- Current landscape of cystic fibrosis gene therapy.Frontiers in pharmacology · 2024Review
- Use of adenine base editing and homology-independent targeted integration strategies to correct the cystic fibrosis causing variant, W1282X.Human molecular genetics · 2023Article
- Review
- Protospacer modification improves base editing of a canonical splice site variant and recovery of CFTR function in human airway epithelial cells.Molecular therapy. Nucleic acids · 2023Article
- Article
- ABCA3 Deficiency-Variant-Specific Response to Hydroxychloroquine.International journal of molecular sciences · 2023Article
- Cystic fibrosis transmembrane conductance regulator in COPD: a role in respiratory epithelium and beyond.The European respiratory journal · 2023Review
Corrections and comments
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Authors and funding
18 authors at 8 institutions in 3 countries.
Allison F McCague1 McKusick-Nathans Institute of Genetic Medicine, School of Medicine.
Karen S Raraigh1 McKusick-Nathans Institute of Genetic Medicine, School of Medicine.
Matthew J Pellicore1 McKusick-Nathans Institute of Genetic Medicine, School of Medicine.
Emily F Davis-Marcisak1 McKusick-Nathans Institute of Genetic Medicine, School of Medicine.
Taylor A Evans1 McKusick-Nathans Institute of Genetic Medicine, School of Medicine.
Sangwoo T Han1 McKusick-Nathans Institute of Genetic Medicine, School of Medicine.
Zhongzhou Lu1 McKusick-Nathans Institute of Genetic Medicine, School of Medicine.
Anya T Joynt1 McKusick-Nathans Institute of Genetic Medicine, School of Medicine.
Neeraj Sharma1 McKusick-Nathans Institute of Genetic Medicine, School of Medicine.
Carlo Castellani2 Cystic Fibrosis Center, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Joseph M Collaco3 Eudowood Division of Pediatric Respiratory Sciences, School of Medicine.
Mary Corey4 Research Institute and.
Michelle H Lewis5 Berman Institute of Bioethics, and.
Chris M Penland6 Cystic Fibrosis Foundation, Bethesda, Maryland; and.
Johanna M Rommens7 Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Anne L Stephenson8 Department of Respirology, Adult Cystic Fibrosis Program, St. Michael's Hospital, Toronto, Ontario, Canada.
Patrick R Sosnay9 Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland.
Garry R Cutting1 McKusick-Nathans Institute of Genetic Medicine, School of Medicine.ORCID 0000-0002-8250-8590
Genetic Alliance · USCystic Fibrosis Foundation · USHospital for Sick Children · CAIstituto Giannina Gaslini · ITJohns Hopkins Berman Institute of Bioethics · USJohns Hopkins University · USSt. Michael's Hospital · CATudor Place · US
Funding
Predoctoral Training Program in Human GeneticsT32GM007814 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 1985 to 2021
$10.6MMOLECULAR GENETICS OF CYSTIC FIBROSISR01DK044003 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Garry R Cutting · 1991 to 2026
$6.7MMultidisciplinary Training Program in Pediatric PulmonaryT32HL072748 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Joseph Michael Collaco · 2003 to 2026
$6.1MGene-Environment Interactions in Cystic Fibrosis Lung DiseaseR01HL128475 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI COLLACO, JOSEPH MICHAEL · 2016 to 2019
$1.1MNHLBI NIH HHS R01 HL128475NHLBI NIH HHS T32 HL072748NIDDK NIH HHS R01 DK044003NIGMS NIH HHS T32 GM007814
Abstract
PubMed holds no abstract for this paper.
Indexed as
AdolescentAdultChildCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorFemaleForced Expiratory VolumeGenetic Association StudiesHumansMaleMiddle AgedPrecision MedicineYoung AdultCFTR protein, humanCystic Fibrosis Transmembrane Conductance Regulatorcystic fibrosis transmembrane conductance regulator modulatorgenotype–phenotypelung functionsweat chloride
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.