Evidence map›Paper›PMID 30888730›Full record

SynthesisJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2019

Meta-Analysis of Genomewide Association Studies Reveals Genetic Variants for Hip Bone Geometry.

Yi-Hsiang Hsu, Karol Estrada, Evangelos Evangelou, Cheryl Ackert-Bicknell, Kristina Akesson, Thomas Beck, Suzanne J Brown, Terence Capellini, Laura Carbone, Jane Cauley and 42 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Article
  7. Observational
  8. Effects of femoral neck width and hip axis length on incident hip fracture risk: a registry-based cohort study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
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  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

52 authors.

Yi-Hsiang HsuHinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA.
Karol EstradaBroad Institute, Cambridge, MA.
Evangelos EvangelouDepartment of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, 45110, Greece.
Cheryl Ackert-BicknellCenter for Musculoskeletal Research, Department of Orthopaedics, University of Rochester, Rochester, New York, USA.
Kristina AkessonDepartment of Clinical Sciences Malmö, Lund University, Sweden.
Thomas BeckBeck Radiological Innovations, Baltimore, MD.
Suzanne J BrownDepartment of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Australia.
Terence CapelliniDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA.
Laura CarboneDepartment of Medicine at the Medical College of Georgia at Augusta University, Augusta, GA.
Jane CauleyDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
Ching-Lung CheungDepartment of Medicine, The University of Hong Kong, Hong Kong, China.
Steven R CummingsCalifornia Pacific Medical Center Research Institute, San Francisco, CA.
Stefan CzerwinskiUniversity of Texas, School of Public Health at Bronwsville, TX.
Serkalem DemissieDepartment of Biostatistics, Boston University School of Public Health, Boston, MA.
Michael EconsDepartment of Medicine and Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN.
Daniel EvansCalifornia Pacific Medical Center Research Institute, San Francisco, CA.
Charles FarberPublic Health Sciences, University of Virginia, Charlottesville, VA.
Kaare GautvikLovisenberg Diakonale Hospital, Unger-Vetlesen Institute, and University of Oslo, Institute of Basic Medical Sciences, Oslo, Norway.
Tamara HarrisLaboratory of Epidemiology and Population Sciences, Intramural Research Program, NIA, Bethesda, MD.
Candace KammererDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
John KempUniversity of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia.
Daniel L KollerDepartment of Medicine and Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN.
Annie KungDepartment of Medicine, The University of Hong Kong, Hong Kong, China.
Debbie LawlorMRC Integrative Epidemiology Unit, University of Bristol, UK.
Miryoung LeeUniversity of Texas, School of Public Health at Bronwsville, TX.
Mattias LorentzonDepartment of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE-413 45, Gothenburg, Sweden.
Fiona McGuiganCenter for Musculoskeletal Research, Department of Orthopaedics, University of Rochester, Rochester, New York, USA.
Carolina Medina-GomezDepartment of Epidemiology, Erasmus MC, 3000 CA, Rotterdam, the Netherlands.
Braxton MitchellProgram in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, and Geriatric Research and Education Clinical Center - Veterans Administration Medical Center, Baltimore, MD.
Anne NewmanDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
Carrie NielsonOregon Health & Science University, Portland, OR.
Claes OhlssonDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE-413 45, Gothenburg, Sweden.
Munro PeacockDepartment of Medicine and Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN.
Sjur ReppeLovisenberg Diakonale Hospital, Unger-Vetlesen Institute, and University of Oslo, Institute of Basic Medical Sciences, Oslo, Norway.
J Brent RichardsDepartment of Human Genetics, McGill University, and Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
John RobbinsDepartment of Medicine, University California at Davis, Sacramento, CA.
Gunnar SigurdssonFaculty of Medicine, University of Iceland, Reykjavík, Iceland.
Timothy D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Campus, London, UK.
Kari StefanssondeCODE Genetics, 101 Reykjavik, Iceland.
Elizabeth StreetenProgram in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, and Geriatric Research and Education Clinical Center - Veterans Administration Medical Center, Baltimore, MD.
Unnur StyrkarsdottirdeCODE Genetics, 101 Reykjavik, Iceland.
Jonathan TobiasMusculoskeletal Research Unit, University of Bristol, UK.
Katerina TrajanoskaDepartment of Epidemiology, Erasmus MC, 3000 CA, Rotterdam, the Netherlands.
André UitterlindenDepartment of Internal Medicine, Erasmus MC, 3000 CA, Rotterdam, the Netherlands.
Liesbeth VandenputDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE-413 45, Gothenburg, Sweden.
Scott G WilsonDepartment of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Australia.
Laura Yerges-ArmstrongGenetics, GlaxoSmithKline, King of Prussia, PA.
Mariel YoungDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA.
M Carola ZillikensDepartment of Internal Medicine, Erasmus MC, 3000 CA, Rotterdam, the Netherlands.
Fernando RivadeneiraDepartment of Internal Medicine, Erasmus MC, 3000 CA, Rotterdam, the Netherlands.
Douglas P KielHinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA.
David KarasikHinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA.

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Study of Osteoporotic FracturesR01AG005407 · NIA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI CUMMINGS, STEVEN RON, YAFFE, KRISTINE · 1986 to 2016
$23.2M
Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D · 2005 to 2019
$17.3M
SUBCUTANEOUS FAT, BLOOD LIPIDS AND SUBSEQUENT OUTCOMER01HD012252 · NICHD · WRIGHT STATE UNIVERSITY · PI CZERWINSKI, STEFAN A. · 1985 to 2014
$17.3M
RISK FACTORS FOR VERTEBRAL FRACTURE AND BONE LOSSR01AR041398 · NIAMS · RHODE ISLAND HOSPITAL (PROVIDENCE, RI) · PI KIEL, DOUGLAS P. · 1991 to 2025
$16.1M
UCLA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033176 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2011 to 2011
$15.5M
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
The Gut Microbiome and Bone MicroarchitectureR01AR061445 · NIAMS · HEBREW REHABILITATION CENTER FOR AGED · PI KIEL, DOUGLAS P. · 2012 to 2021
$8.9M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
NCATS NIH HHS UL1 TR001108NCATS NIH HHS UL1 TR001881NCRR NIH HHS UL1 RR033176NHGRI NIH HHS HHSN268200782096CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC075150NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085084NHLBI NIH HHS N01 HC085085NHLBI NIH HHS N01 HC085086NHLBI NIH HHS R01 HL080295NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIAMS NIH HHS F32 AR059469NIAMS NIH HHS R01 AR035582NIAMS NIH HHS R01 AR035583NIAMS NIH HHS R01 AR035584NIAMS NIH HHS R01 AR041398NIAMS NIH HHS R01 AR046838NIAMS NIH HHS R01 AR050066NIAMS NIH HHS R01 AR052147NIAMS NIH HHS R01 AR057118NIAMS NIH HHS R01 AR061162NIAMS NIH HHS R01 AR061445NIAMS NIH HHS R01 AR070139NIAMS NIH HHS R01 AR072199NIAMS NIH HHS RC2 AR058973NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS R01 AG005394NIA NIH HHS R01 AG005407NIA NIH HHS R01 AG015928NIA NIH HHS R01 AG020098NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG027058NIA NIH HHS R01 AG027574NIA NIH HHS R01 AG027576NIA NIH HHS R01 AG032098NIA NIH HHS R01 AG041517NIA NIH HHS R56 AG020098NIA NIH HHS R56 AG023629NIA NIH HHS U24 AG051129NICHD NIH HHS R01 HD012252NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK072488Wellcome Trust
6 · The paper itself

Abstract

Hip geometry is an important predictor of fracture. We performed a meta-analysis of GWAS studies in adults to identify genetic variants that are associated with proximal femur geometry phenotypes. We analyzed four phenotypes: (i) femoral neck length; (ii) neck-shaft angle; (iii) femoral neck width, and (iv) femoral neck section modulus, estimated from DXA scans using algorithms of hip structure analysis. In the Discovery stage, 10 cohort studies were included in the fixed-effect meta-analysis, with up to 18,719 men and women ages 16 to 93 years. Association analyses were performed with ∼2.5 million polymorphisms under an additive model adjusted for age, body mass index, and height. Replication analyses of meta-GWAS significant loci (at adjusted genomewide significance [GWS], threshold p ≤ 2.6 × 10

Indexed as

Genetic VariationGenome-Wide Association StudyAdultAnimalsCells, CulturedCortical BoneEpigenesis, GeneticFemaleGene Expression RegulationGene Regulatory NetworksHip FracturesHumansLinkage DisequilibriumMaleMicePelvic BonesRNA, MessengerCANDIDATE GENESFRACTURE, GENOMEWIDE ASSOCIATION STUDYHIP BONE GEOMETRYMETA-ANALYSISPOLYMORPHISMS

Identifiers

PMID30888730
PMCPMC6650334

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.