ArticleProbiotics and antimicrobial proteins2020
Probiotic Activity of Enterococcus faecium and Lactococcus lactis Isolated from Thai Fermented Sausages and Their Protective Effect Against Clostridium difficile.
Article in Probiotics and antimicrobial proteins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Comprehensive Evaluation of Safety, Functional Properties, and Immunomodulatory Activity of 19 Probiotic Strains Approved by the Ministry of Food and Drug Safety (MFDS).Journal of microbiology and biotechnology · 2026Article
- Exploring the Probiotic Potential and Immunomodulatory Capacity of Lactococcus lactis NCDO 2118 Against Bacterial Pathogens and Trypanosoma cruzi.Probiotics and antimicrobial proteins · 2026Article
- Assessment of pathogenic potential in non-pathogenic industrially relevant bacteria.Access microbiology · 2026Article
- Probiotic Antimicrobial Evaluation Via Real-Time Profiling of Bacterial Cell Proliferation Using Stochastic Kinetics.ACS sensors · 2025Article
- The gut microbiome, immune modulation, and cognitive decline: insights on the gut-brain axis.Frontiers in immunology · 2025Review
- Probiotic evaluation, adherence capability and safety assessment of Lactococcus lactis strain isolated from an important herb "Murraya koenigii".Scientific reports · 2024Article
- Evaluation of autochthonousFood science and biotechnology · 2024Article
- Lactococcus lactis, a bacterium with probiotic functions and pathogenicity.World journal of microbiology & biotechnology · 2023Review
- Probing the functional and therapeutic properties of postbiotics in relation to their industrial application.Food science & nutrition · 2023Review
- Article
- Bacteriocinogenic probiotic bacteria isolated from an aquatic environment inhibit the growth of food and fish pathogens.Scientific reports · 2022Article
- Systems-Level Analysis of the Global Regulatory Mechanism of CodY in Lactococcus lactis Metabolism and Nisin Immunity Modulation.Applied and environmental microbiology · 2022Article
- Open pangenome ofFrontiers in microbiology · 2022Article
- The effects of polyphenols against oxidative stress inFrontiers in nutrition · 2022Article
- Article
- Intestinal Mucosal Immunity-Mediated Modulation of the Gut Microbiome by Oral Delivery ofFrontiers in immunology · 2022Article
- Isolation and Characterization of Human Intestinal BacteriaFrontiers in microbiology · 2022Article
- Potential ProbioticFoods (Basel, Switzerland) · 2021Article
- Molecular identification and in vitro evaluation of probiotic functional properties of some Egyptian lactic acid bacteria and yeasts.Journal, genetic engineering & biotechnology · 2021Article
- ProteolyticFood technology and biotechnology · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lactic acid bacteria, Enterococcus faecium and Lactococcus lactis, previously isolated from Thai fermented sausages were elucidated their probiotic properties especially in the control of Clostridium difficile 630. Both isolates survived in simulated gastric solution at pH 3 followed in simulated intestinal solution at pH 8. The presence of skimmed milk also helped the bacteria to survive through acidic and alkaline in gastrointestinal conditions. The adhesion properties of both isolates were tested using a human colon adenocarcinoma cell line. The result showed that both isolates exhibited desirable probiotic properties which adhered to Caco-2 cells. The neutralized cell-free supernatant of both isolates demonstrated that no cytotoxicity toward Caco-2 cells vice versa cell-free supernatant of C. difficile 630 toward Caco-2 cell demonstrated high toxicity. The immunomodulation effect in response to bacterial neutralized cell-free supernatant and cell-free supernatant was also studied. The expression level of pro-inflammatory cytokine of Caco-2 cell which are tumor necrosis factor-α and interleukin-8 was evaluated using quantitative reverse transcriptase PCR. Both isolates were able to diminish the expression level of TNF-α and IL-8 induced by the cell-free supernatant of C. difficile 630. Hence, these isolates would be able to improve the gut health through counteracting the C. difficile-associated intestinal inflammation in human cell lines. These results may contribute to the development of the isolates using as probiotics.
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