ArticleInfection2019
Asymptomatic Leishmania infection in blood donors from the Southern of Spain.
Article in Infection, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Patterns and drivers of the distribution of Leishmania infection in humans using environmental and socioeconomic factors: a modeling study in mainland Portugal.Parasites & vectors · 2026Article
- Visceral leishmaniasis in a multiple sclerosis patient: a rare complication of fingolimod-induced lymphopenia.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2026Article
- Quantitative proteomics of infected macrophages reveals novel Leishmania virulence factors.PLoS pathogens · 2026Article
- Assessment of Leishmania exposure in blood donors from a non-endemic urban area: A study in São Paulo.Vox sanguinis · 2026Article
- Agreement Document for the Study of Leishmaniasis from a One Health Approach in Spain.Tropical medicine and infectious disease · 2025Article
- Seroprevalence of West Nile Virus in Blood Donors in Mainland Portugal.Tropical medicine and infectious disease · 2025Article
- Asymptomatic Leishmania Infection among Blood Donors in a Southern Province of Thailand.The American journal of tropical medicine and hygiene · 2024Article
- Analysis of HLA Alleles in Different Cohorts of Patients Infected byInternational journal of molecular sciences · 2024Article
- Prevalence of Leishmaniasis among Blood Donors: A Systematic Review and Meta-Analysis.Diseases (Basel, Switzerland) · 2024Review
- Erythrocyte sedimentation rate in heartworm naturally infected dogs "with or without"Frontiers in veterinary science · 2024Article
- Asymptomatic Leishmania infantum infection in dogs and dog owners in an endemic area in southeast France.Parasite (Paris, France) · 2024Article
- Prevalence of asymptomatic Leishmania infection and knowledge, perceptions, and practices in blood donors in mainland Portugal.Parasites & vectors · 2023Article
- Prevalence and Factors Related toAnimals : an open access journal from MDPI · 2023Article
- The estimated distribution of autochthonous leishmaniasis by Leishmania infantum in Europe in 2005-2020.PLoS neglected tropical diseases · 2023Review
- Evaluation of Molecular Methods to Identify Chagas Disease and Leishmaniasis in Blood Donation Candidates in Two Brazilian Centers.Pathogens (Basel, Switzerland) · 2023Article
- Laboratory diagnostics for human Leishmania infections: a polymerase chain reaction-focussed review of detection and identification methods.Parasites & vectors · 2022Review
- Leishmaniasis vectors in the environment of treated leishmaniasis cases in Spain.Transboundary and emerging diseases · 2022Article
- Exposure to Phlebotomus perniciosus sandfly vectors is positively associated with Toscana virus and Leishmania infantum infection in human blood donors in Murcia Region, southeast Spain.Transboundary and emerging diseases · 2022Article
- Identification of asymptomatic Leishmania infections: a scoping review.Parasites & vectors · 2022Article
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Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo investigate the proportion of asymptomatic infection among blood donors in a region endemic for Leishmania; and to ascertain epidemiological and genetic factors associated with this condition.
methodsWe studied 1260 blood donors in the Province of Granada in the Southern Spain. After obtaining informed consent in each participant, a poll about habits, housing and contact with animals were carried out. Blood samples were obtained for determining antileishmanial antibodies and a PCR assay. HLA typing was performed in a randomly sample among the donors with positive serology.
resultsWe have found that L. infantum antibodies were present in 7.9% of blood donors and DNA in blood was detected in 2.5% of donors. There was no concordance between both determinations, except in one patient. Taking into consideration both techniques, 129 participants were considered to have asymptomatic Leishmania infection. No participant in this study developed clinical leishmaniasis during a follow-up period of 2 years. HLA were typed in 51 donors. Asymptomatic Leishmania infection might be associated with certain HLA antigens. A multivariate analysis was done with the variables obtained through the participants' interview. The contact with livestock (goats, pigs, and sheep), but not dogs, either at home or in the environment, was significantly and independently associated with asymptomatic leishmania infection.
conclusionsAsymptomatic leishmanial infection among blood donors is frequent in the Granada Province, south of Spain. The presence of livestock in this region is related to this infection, perhaps influencing vector density of this disease. Some HLA genes might be associated with asymptomatic leishmanial state.
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