Evidence map›Paper›PMID 30888503›Full record

ArticleHistochemistry and cell biology2019

Similarities and differences in tissue distribution of DLK1 and DLK2 during E16.5 mouse embryogenesis.

P Garcia-Gallastegi, A Ruiz-García, G Ibarretxe, S Rivero-Hinojosa, A D González-Siccha, J Laborda, O Crende, F Unda, J J García-Ramírez

Erratum issuedOpen access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Histochemistry and cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Cell signaling regulation in salivary gland development.Cellular and molecular life sciences : CMLS · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

P Garcia-GallastegiDepartment of Cell Biology and Histology, Faculty of Medicine and Nursing, University of the Basque Country, UPV/EHU, 48940, Leioa, Bizkaia, Spain.
A Ruiz-GarcíaDepartment of Inorganic and Organic Chemistry and Biochemistry, Medical School, Regional Center for Biomedical Research, Unidad Asociada de Biomedicina (UCLM-CSIC), University of Castilla-La Mancha, Calle Almansa 14, 02008, Albacete, Spain.
G IbarretxeDepartment of Cell Biology and Histology, Faculty of Medicine and Nursing, University of the Basque Country, UPV/EHU, 48940, Leioa, Bizkaia, Spain.
S Rivero-HinojosaCenter for Cancer and Immunology Research, Children's Research Institute, National Health System, 111 Michigan Ave NW, Washington, DC, 20010, USA.
A D González-SicchaDepartamento de Bioquímica, Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, Av. Juan Pablo II s/n, Trujillo, Peru.
J LabordaDepartment of Inorganic and Organic Chemistry and Biochemistry, Pharmacy School, Regional Center for Biomedical Research, Unidad Asociada de Biomedicina (UCLM-CSIC), University of Castilla-La Mancha, Avda José María Sánchez Ibáñez s/n, 02008, Albacete, Spain.
O CrendeDepartment of Cell Biology and Histology, Faculty of Medicine and Nursing, University of the Basque Country, UPV/EHU, 48940, Leioa, Bizkaia, Spain.
F UndaDepartment of Cell Biology and Histology, Faculty of Medicine and Nursing, University of the Basque Country, UPV/EHU, 48940, Leioa, Bizkaia, Spain. fernando.unda@ehu.es.ORCID http://orcid.org/0000-0001-7616-5280
J J García-RamírezDepartment of Inorganic and Organic Chemistry and Biochemistry, Medical School, Regional Center for Biomedical Research, Unidad Asociada de Biomedicina (UCLM-CSIC), University of Castilla-La Mancha, Calle Almansa 14, 02008, Albacete, Spain.
University of the Basque Country · ESUniversity of Castilla-La Mancha · ESChildren's National · USNational University of Trujillo · PE

Funding

Consejería de Educación, Junta de Castilla y León PPII-2014-018-PEuskal Herriko Unibertsitatea GIU16/66
6 · The paper itself

Abstract

DLK1 and DLK2 are transmembrane proteins belonging to the EGF-like repeat-containing family that function as non-canonical NOTCH inhibitory ligands. DLK1 is usually downregulated after embryo development and its distribution in some adult and embryonic tissues has been described. However, the expression and role of DLK2 in embryo and adult tissues remains unclear. To better understand the relevance of both proteins during embryo development, we analyzed the expression pattern of DLK1 and DLK2 in 16.5-day-old mouse embryos (E16.5) and evaluated the possible relationship between these two proteins in embryo tissues and cell types. We found that DLK1 and DLK2 proteins exhibited a broad distribution pattern, which was detected in developing mouse organs from each of the three germ layers: ectoderm (brain, salivary glands), mesoderm (skeletal muscle, vertebral column, kidney, cartilage), and endoderm (thymus, lung, pancreas, intestine, liver). The expression pattern of DLK1 and DLK2 indicates that both proteins could play a synergistic role during cell differentiation. This study provides additional information for understanding temporal and site-specific effects of DLK1 and DLK2 during embryo morphogenesis and cell differentiation.

Indexed as

Embryonic DevelopmentAnimalsCalcium-Binding ProteinsCell DifferentiationIntercellular Signaling Peptides and ProteinsMiceCalcium-Binding ProteinsDlk1 protein, mouseDlk2 protein, mouseIntercellular Signaling Peptides and ProteinsDLK1DLK2Embryo developmentTissue distribution

Identifiers

PMID30888503
OpenAlexW2923648696

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.