ArticleEuropean radiology2019
US-guided microwave ablation for primary hyperparathyroidism: a safety and efficacy study.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Percutaneous microwave ablation of hyperfunctioning parathyroid lesions under multiparametric ultrasound guidance for primary hyperparathyroidism: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Complications in chemical and thermal ablation of parathyroid lesions: a systematic review and meta-analysis.European radiology · 2025Pooled it
- Efficacy and safety of ultrasound-guided microwave ablation for primary hyperparathyroidism: a dual-centre study.Scientific reports · 2026Article
- Thermal ablation for primary hyperparathyroidism: long-term follow-up results.European radiology · 2026Article
- Safety and efficacy of ultrasound-guided microwave ablation in patients with primary hyperparathyroidism: a single-center retrospective study.Quantitative imaging in medicine and surgery · 2026Article
- Short-term biochemical outcomes after microwave ablation versus parathyroidectomy for primary hyperparathyroidism: an IPTW analysis.Frontiers in endocrinology · 2026Article
- Efficacy and safety of radiofrequency ablation for secondary hyperparathyroidism: a systematic review and meta-analysis.Asian biomedicine : research, reviews and news · 2024Article
- Radiofrequency ablation as a treatment modality for primary hyperparathyroidism: a systematic literature review.Gland surgery · 2024Review
- Case report: Microwave ablation is a safe and effective method for primary hyperparathyroidism in pregnancy.Frontiers in medicine · 2024Article
- Efficacy and safety of radiofrequency ablation for primary and secondary hyperparathyroidism: a retrospective study.Scientific reports · 2023Article
- Predicting ultrasound-guided thermal ablation benefit in primary hyperparathyroidism.European radiology · 2022Article
- Efficacy and Safety of Ultrasound-Guided Radiofrequency Ablation for Primary Hyperparathyroidism: A Prospective Study.Korean journal of radiology · 2022Article
- Evaluation of efficacy of ultrasound-guided microwave ablation in primary hyperparathyroidism.Journal of clinical ultrasound : JCU · 2022Article
- Long-Term Effect of Microwave Ablation on Patients Undergoing Hemodialysis for Moderate Secondary Hyperparathyroidism: A Retrospective Cohort Study.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2021Observational
- A study on the causes of operative failures after microwave ablation for primary hyperparathyroidism.European radiology · 2021Article
- [Normocalcemic with elevated post-operative parathormone in primary hyperpara-thyroidism: 9 case reports and literature review].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2021Review
- Article
- Bone Turnover Markers in Response to Ultrasound-Guided Microwave Ablation for Primary Hyperparathyroidism.Frontiers in endocrinology · 2021Article
- Minimally Invasive Treatment for Benign Parathyroid Lesions: Treatment Efficacy and Safety Based on Nodule Characteristics.Korean journal of radiology · 2020Article
- Comparison of microwave ablation treatments in patients with renal secondary and primary hyperparathyroidism.Renal failure · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo evaluate the safety and efficacy of microwave ablation (MWA) with the assistance of continuous cool saline injection (CCSI) in patients with primary hyperparathyroidism (PHPT).
methodsBetween November 1, 2014, and February 29, 2016, 22 patients with PHPT were enrolled and treated with ultrasound-guided MWA assisted by CCSI. The levels of parathyroid hormone (PTH) and serum calcium were recorded before and after the MWA. Patients were divided into two groups (normalized and unnormalized groups) according to treatment efficacy. Fisher's exact test and the Mann-Whitney test were used to compare data between the two groups. Timing differences in serum PTH and calcium levels were analyzed with repeated measures analysis of variance.
resultsNormalized outcomes for both PTH and calcium levels were achieved in 19 of 22 (86.36%) patients with PHPT. In the normalized group, PTH levels remained normal for 12 months after MWA. PTH levels in the unnormalized group were outside the reference range at six of seven follow-ups within 12 months following MWA. By contrast, serum calcium levels gradually decreased in all patients in both groups. The mean serum PTH and mean calcium levels at 6 months after therapy were significantly lower than those before MWA (both p < 0.05). A transient voice change developed in eight patients. One patient experienced hypocalcaemia, which was corrected by oral calcium supplementation within 2 months.
conclusionsUS-guided MWA assisted by CCSI is safe and effective for destroying parathyroid gland tissue and may serve as a therapeutic alternative for patients with PHPT. KEY POINTS: • Microwave ablation is a new option for patients with hypercalcemic or normocalcemic primary hyperparathyroidism. • Microwave ablation can decrease PTH and calcium levels with sustained efficacy in most patients. • Treatment is safe and causes only transient side effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.