ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2019
Matrix-associated stem cell transplantation is successful in treating talar osteochondral lesions.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Prognostic factors for the management of chondral defects of the knee and ankle joint: a systematic review.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Pooled it
- Cell therapies for chondral defects of the talus: a systematic review.Journal of orthopaedic surgery and research · 2022Pooled it
- Limitations of accessibility of the talar dome with different open surgical approaches.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Pooled it
- Functional and radiographic outcomes of talar osteochondral lesions repaired with a combination of autologous bone graft, cell-free hyaluronic acid-based scaffold, bone marrow aspirate concentrate (BMAC) and fibrin glue.International orthopaedics · 2025Article
- Typical Complications After Cartilage Repair of the Ankle Using Autologous Matrix-Induced Chondrogenesis (AMIC).Foot & ankle orthopaedics · 2023Article
- Autologous matrix induced chondrogenesis (AMIC) as revision procedure for failed AMIC in recurrent symptomatic osteochondral defects of the talus.Scientific reports · 2022Article
- Reorientation technique has benefits in bone marrow aspiration of stem cells.Scientific reports · 2022Article
- [Expert consensus on surgical treatment of patellofemoral osteoarthritis].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2021Article
- Osteochondral lesions of the talus.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOsteochondral lesions (OCLs) of the talus are a challenging and increasingly recognized problem in chronic ankle pain. Many novel techniques exist to try and treat this challenging entity. Difficulties associated with treating OCLs include lesion location, size, chronicity, and problems associated with potential graft harvest sites. Matrix-associated stem cell transplantation (MAST) is one such treatment described for larger lesions > 15 mm
methodsA review of all patients treated with MAST by a single surgeon was conducted. Pre-operative radiographs, MRIs, and FAOS outcome questionnaire scores were reviewed. Intraoperative classification was undertaken to correlate with imaging. Post-operative outcomes included FAOS scores, return to sport, revision surgery/failure of treatment, and progression to ankle fusion.
resultsIn this study, 38 OCLs in 32 patients were identified. Median patient age was 35 years of which (68.8%) were male. Median length of follow-up was 36.7 months (range 12-64 months). (83%) returned to playing sport. Twenty-three patients underwent MAST in the setting of a failed previous operative attempt, with just nine having MAST as a first option. Nine patients out of 32 had a further procedure. Improvements were seen in all domains of the FAOS (p < 0.05).
conclusionMAST has demonstrated encouraging results in lesions which prove challenging to treat, even in a "failed microfracture" cohort. LEVEL OF EVIDENCE: IV.
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