ArticleeLife2019
Open access · goldAbstract read
In one paragraph
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
8.4field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 72 citations in OpenAlex.
- Review
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- Unpacking boxes: identification of novel inhibitors of malaria parasite invasion.International journal for parasitology. Drugs and drug resistance · 2026Article
- Cellular and molecular basis of PfCoronin function in artemisinin resistance in Plasmodium falciparum.Nature communications · 2026Article
- A bridge-like lipid transfer protein is critical for generation of invasive stages in malaria parasites.Nature communications · 2026Article
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- Pivotal roles of Plasmodium falciparum lysophospholipid acyltransferase 1 in cell cycle progression and cytostome internalization.Communications biology · 2025Article
- Mutational analysis of an antimalarial drug target,Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Targeting Malaria's Achilles' Heels: A Review of Plasmodium Life Cycle Vulnerabilities for Drug Discovery.Current topics in medicinal chemistry · 2025Review
- TheScience advances · 2024Article
- Harnessing cholesterol uptake of malaria parasites for therapeutic applications.EMBO molecular medicine · 2024Article
- The intersection of hostMicrobiology and molecular biology reviews : MMBR · 2024Review
- Understanding theFrontiers in parasitology · 2024Review
- Article
- Antimalarial drug discovery: progress and approaches.Nature reviews. Drug discovery · 2023Review
- Mining gene expression data for rational identification of novel drug targets and vaccine candidates against the cattle tick, Rhipicephalus microplus.Experimental & applied acarology · 2023Article
- Profile of Daniel E. Goldberg.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Activation of themBio · 2023Article
- Malaria therapeutics: are we close enough?Parasites & vectors · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 1 country.
Eva S Istvan *Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, Saint Louis, United States.ORCID 0000-0002-8666-3248
Sudipta Das *Department of Microbiology and Immunology, Center for Molecular Parasitology, Drexel University College of Medicine, Philadelphia, United States.
Suyash BhatnagarDepartment of Microbiology and Immunology, Center for Molecular Parasitology, Drexel University College of Medicine, Philadelphia, United States.
Josh R BeckDepartment of Medicine, Division of Infectious Diseases, Washington University School of Medicine, Saint Louis, United States.ORCID 0000-0001-6196-8689
Edward OwenDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, United States.
Manuel LlinasDepartment of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, United States.ORCID 0000-0002-6173-5882
Suresh M GanesanDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, United States.
Jacquin C NilesDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, United States.
Elizabeth WinzelerDepartment of Pediatrics, University of California San Diego School of Medicine, La Jolla, United States.ORCID 0000-0002-4049-2113
Akhil B VaidyaDepartment of Microbiology and Immunology, Center for Molecular Parasitology, Drexel University College of Medicine, Philadelphia, United States.ORCID 0000-0003-1063-5571
Daniel E GoldbergDepartment of Medicine, Division of Infectious Diseases, Washington University School of Medicine, Saint Louis, United States.ORCID 0000-0003-3529-8399
Drexel University · USMassachusetts Institute of Technology · USPennsylvania State University · USWashington University in St. Louis · USIowa State University · USUniversity of California San Diego · US
Funding
ORGANELLE GENOMES OF MALARIAL PARASITESR01AI028398 · NIAID · MCP HAHNEMANN UNIVERSITY · PI AKHIL B VAIDYA · 1989 to 2026
$10.1MMolecular Pathways Affected by Drugs that Disrupt Na+ Homeostasis in Malaria ParasitesR01AI132508 · NIAID · DREXEL UNIVERSITY · PI AKHIL B VAIDYA · 2017 to 2026
$5.7MDiscovery of chemically validated malaria liver stage targetsR01AI090141 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WINZELER, ELIZABETH A · 2011 to 2019
$3.4MDefining the targets of broad intervention antimalarial agentsR01AI103058 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WINZELER, ELIZABETH A · 2013 to 2016
$2.6MEngineered Regulated RNA Localization and Transport in Biological SystemsDP2OD007124 · OD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI NILES, JACQUIN C · 2010 to 2010
$2.5MMolecular Pathways Targeted by Potent Antimalarial Pyrazole CompoundsR01AI098413 · NIAID · DREXEL UNIVERSITY · PI VAIDYA, AKHIL B · 2012 to 2015
$1.9MErythrocyte Subversion by Malaria Parasite Exported EffectorsR00HL133453 · NHLBI · IOWA STATE UNIVERSITY · PI BECK, JOSH RYAN · 2017 to 2019
$747kErythrocyte Subversion by Malaria Parasite Exported EffectorsK99HL133453 · NHLBI · WASHINGTON UNIVERSITY · PI BECK, JOSH RYAN · 2016 to 2017
$166kBill and Melinda Gates Foundation OPP 1054480Bill and Melinda Gates Foundation OPP1132313National Institute of Allergy and Infectious Diseases R01AI098413National Institute of Allergy and Infectious Diseases R01AI132508NHLBI NIH HHS K99 HL133453NHLBI NIH HHS K99/R00 HL133453NHLBI NIH HHS R00 HL133453NIAID NIH HHS R01 AI028398NIAID NIH HHS R01 AI090141NIAID NIH HHS R01 AI098413NIAID NIH HHS R01 AI103058NIAID NIH HHS R01 AI132508NIH HHS 1DP2OD007124NIH HHS DP2 OD007124
Abstract
Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter).
Indexed as
Cell MembraneGene Knockdown TechniquesHomeostasisNiemann-Pick C1 ProteinPlasmodium falciparumProtozoan ProteinsNiemann-Pick C1 ProteinProtozoan Proteinsantimalarialcholesteroldigestive vacuoleinfectious diseasemicrobiologyP. falciparum
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.