Evidence map›Paper›PMID 30888317›Full record

ArticleeLife2019

Dissociation rate compensation mechanism for budding yeast pioneer transcription factors.

Benjamin T Donovan, Hengye Chen, Caroline Jipa, Lu Bai, Michael G Poirier

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 100 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Cohesin Facilitates Nucleosome Invasion by Transcription Factors.bioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
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  17. Article
  18. Article
  19. Article
  20. Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Benjamin T DonovanBiophysics Graduate Program, The Ohio State University, Columbus, United States.ORCID 0000-0003-0177-799X
Hengye ChenDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, State College, United States.
Caroline JipaDepartment of Physics, The Ohio State University, Columbus, United States.
Lu BaiDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, State College, United States.ORCID 0000-0003-3667-2944
Michael G PoirierBiophysics Graduate Program, The Ohio State University, Columbus, United States.ORCID 0000-0002-1563-5792
The Ohio State University · USPennsylvania State University · US

Funding

Cellular, molecular, and biochemical sciences training grantT32GM086252 · NIGMS · OHIO STATE UNIVERSITY · PI JACKMAN, JANE ELIZABETH, MUSIER-FORSYTH, KARIN M · 2011 to 2020
$2.0M
Mechanistic study of pioneer factorsR01GM121858 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI BAI, LU · 2017 to 2020
$1.2M
Regulatory Mechanisms of Linker Histones and Their Post-Translational ModificationsR01GM121966 · NIGMS · OHIO STATE UNIVERSITY · PI POIRIER, MICHAEL GUY · 2017 to 2020
$1.2M
National Science Foundation 1516979NIGMS NIH HHS R01 GM121858NIGMS NIH HHS R01 GM121966NIH HHS R01 GM121966NIH HHS T32 GM086252
6 · The paper itself

Abstract

Nucleosomes restrict the occupancy of most transcription factors (TF) by reducing binding and accelerating dissociation, while a small group of TFs have high affinities to nucleosome-embedded sites and facilitate nucleosome displacement. To understand this process mechanistically, we investigated two

Indexed as

Basic Helix-Loop-Helix Leucine Zipper Transcription FactorsDNA-Binding ProteinsDNA, FungalHistonesNucleosomesProtein BindingSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription FactorsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCBF1 protein, S cerevisiaeDNA-Binding ProteinsDNA, FungalHistonesNucleosomesREB1 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsTranscription Factorsbinding and dissociation kineticschromosomesgene expressionmolecular biophysicsnucleosomespioneer factorsReb1S. cerevisiaesingle moleculestructural biology

Identifiers

PMID30888317
PMCPMC6449090
OpenAlexW2949677888

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.