Learning from Solar Energy Conversion: Biointerfaces for Artificial Photosynthesis and Biological Modulation.

Three seemingly distinct directions of nanomaterials research, photovoltaics, biofuel production, and biological modulation, have been sequentially developed over the past several decades. In this Mini Review, we discuss how the insights gleaned from nanomaterials-based solar energy conversion can be adapted to biointerface designs. Because of their size- and shape-dependent optical properties and excellent synthetic control, nanomaterials have shown unique technological advantages as the light absorbers or energy transducers. Biocompatible nanomaterials have also been incorporated into biological systems including biomolecules, bacteria, and eukaryotic cells for a large collection of fundamental studies and applications. For the photocatalytic biofuel production, either isolated bacterial enzymes or the entire bacteria have been hybridized with the nanomaterials, where functions from both parts are synergistically integrated. Likewise, interfacing nanomaterials with eukaryotic systems, whether in individual cells or tissues, has enabled optical modulation of cellular behavior and the construction of active cellular materials. Here we survey different approaches in which nanomaterials are used to elicit electrical or mechanical changes in single cells or cellular assemblies via photoelectrochemical or photothermal processes. We end this Mini Review with the discussion of future nongenetic modulation at the intracellular level.