ArticleThe journal of physical chemistry. B2019
Molecular Origin of the Elastic State of Aqueous Hyaluronic Acid.
Article in The journal of physical chemistry. B, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 55 citations in OpenAlex.
- Dynamics of Solvating Water As a Probe of Polymers and Supramolecular Structures.Chemical reviews · 2026Review
- Transient formation of supramolecular complexes between hyaluronan and oligopeptides at submicromolar concentration.Communications chemistry · 2026Article
- Modulating Rheological Properties via Non-Cross-Linked Phase in Biphasic Hyaluronic Acid Fillers.ACS omega · 2025Article
- Molecular Mechanisms and Therapeutic Role of Intra-Articular Hyaluronic Acid in Osteoarthritis: A Precision Medicine Perspective.Journal of clinical medicine · 2025Review
- Kinetic and Mechanistic Release Studies on Hyaluronan Hydrogels for Their Potential Use as a pH-Responsive Drug Delivery Device.Gels (Basel, Switzerland) · 2024Article
- Modular and Photoreversible Polymer-Nanoparticle Hydrogels via Host-Guest Interactions.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Temperature-Regulated Synthesis of Hyaluronic Acid-Interpenetrated Polyacrylamide/Poly(Acrylic Acid Sodium Salt) Semi-Interpenetrated Polymer Network Gel for the Removal of Methyl Violet.Gels (Basel, Switzerland) · 2024Article
- Multiphoton lithography with protein photoresists.Materials today. Bio · 2024Article
- Glycosaminoglycans: What Remains To Be Deciphered?JACS Au · 2023Review
- Bioinspired Processing of Keratin into Upcycled Fibers through pH-Induced Coacervation.ACS sustainable chemistry & engineering · 2023Article
- Prospective bacterial and fungal sources of hyaluronic acid: A review.Computational and structural biotechnology journal · 2022Review
- Molecular Structure and Surface Accumulation Dynamics of Hyaluronan at the Water-Air Interface.Macromolecules · 2021Article
- Stringiness of hyaluronic acid emulsions.International journal of cosmetic science · 2021Article
- Structure and Dynamics of a Temperature-Sensitive Hydrogel.The journal of physical chemistry. B · 2021Article
- The CNS/PNS Extracellular Matrix Provides Instructive Guidance Cues to Neural Cells and Neuroregulatory Proteins in Neural Development and Repair.International journal of molecular sciences · 2021Review
- Connecting the Stimuli-Responsive Rheology of Biopolymer Hydrogels to Underlying Hydrogen-Bonding Interactions.Macromolecules · 2020Article
- Direct Observation of Intrachain Hydrogen Bonds in Aqueous Hyaluronan.The journal of physical chemistry. A · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The macroscopic mechanical properties of biological hydrogels are broadly studied and successfully mimicked in synthetic materials, but little is known about the molecular interactions that mediate these properties. Here, we use two-dimensional infrared spectroscopy to study the pH-induced gelation of hyaluronic acid, a ubiquitous biopolymer, which undergoes a transition from a viscous to an elastic state in a narrow pH range around 2.5. We find that the gelation originates from the enhanced formation of strong interchain connections, consisting of a double amide-COOH hydrogen bond and an N-D-COO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.