Evidence map›Paper›PMID 30888118›Full record

Trial reportCancer medicine2019

Rituximab maintenance overcomes the negative prognostic factor of obesity in CLL: Subgroup analysis of the international randomized AGMT CLL-8a mabtenance trial.

Alexander Egle, Thomas Melchardt, Petra Obrtlíková, Lukáš Smolej, Tomáš Kozák, Michael Steurer, Johannes Andel, Sonja Burgstaller, Eva Mikušková, Liana Gercheva and 27 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Review
  3. Maintenance therapy for chronic lymphocytic leukaemia.The Cochrane database of systematic reviews · 2024
    Review
  4. Article
  5. Article
  6. Global Burden of Chronic Lymphocytic Leukemia From 1990 to 2021.Cancer control : journal of the Moffitt Cancer Center
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 20 institutions in 7 countries.

Alexander EgleThird Medical Department, Paracelsus Medical University Salzburg, Salzburg, Austria.ORCID 0000-0003-0648-4416
Thomas MelchardtThird Medical Department, Paracelsus Medical University Salzburg, Salzburg, Austria.
Petra ObrtlíkováFirst Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic.
Lukáš SmolejFourth Department of Internal Medicine - Hematology, Faculty of Medicine in Hradec Králové, University Hospital and Charles University in Prague, Hradec Králové, Czech Republic.
Tomáš KozákDepartment of Internal Medicine - Hematology, University Hospital Kralovske Vinohrady, Prague, Czech Republic.
Michael SteurerDepartment of Internal Medicine V, Medical University Innsbruck, Innsbruck, Austria.
Johannes AndelInternal Medicine II, Hospital of Steyr, Steyr, Austria.
Sonja BurgstallerDepartment of Internal Medicine IV, Klinikum Wels-Grieskirchen GmbH, Wels, Austria.
Eva MikuškováDepartment of Hemato-oncology 2, National Cancer Institute Bratislava, Bratislava, Slovakia.
Liana GerchevaClinic of Hematology, University Hospital St Marina Varna, Varna, Bulgaria.
Thomas NösslingerThird Medical Department for Hematology and Oncology, Hanusch Krankenhaus der Wiener Gebietskrankenkasse, Vienna, Austria.
Tomáš PapajíkDepartment of Hemato-oncology, University Hospital Olomouc, Olomouc, Czech Republic.
Miriam LadickáDepartment of Clinical Oncology 1, National Cancer Institute Bratislava, Bratislava, Slovakia.
Michael GirschikofskyInterne Abteilung, Ordensklinikum Linz GmbH, Elisabethinen, Linz, Austria.
Mikuláš HrubiškoClinic of Hematology and Transfusiology, Slovak Medical University, University Hospital Bratislava, Bratislava, Slovakia.
Ulrich JägerDepartment of Medicine I, Division of Hematology and Hemostaeology, Medical University Vienna, Vienna, Austria.
Daniela VoskovaDepartment of Internal Medicine 3, Kepler Universitätsklinikum GmbH, Med Campus III., Linz, Austria.
Martin PecherstorferDepartment of Internal Medicine 2, University Hospital Krems, Karl Landsteiner Private University of Health Sciences, Krems, Austria.
Eva KrálikováDepartment of Hematology, FNsP F D Roosevelta Banská Bystrica, Banska Bystrica, Slovakia.
Christina BurcoveanuClinic of Haematology, Regional Institute of Oncology Iasi, Iasi, Romania.
Emil SpasovClinic of Hematology, UMHAT St George and Medical University Plovdiv, Plovdiv, Bulgaria.
Andreas PetzerInnere Medizin I, Ordensklinikum Linz GmbH, Linz, Austria.
Georgi MihaylovHematological Clinic NSHATHD Sofia, Queen Joanna University Hospital, Sofia, Bulgaria.
Julian RaynovClinic of Medical Hematology, Military Medical Academy Sofia, Sofia, Bulgaria.
Horst OexleInnere Medizin, Landeskrankenhaus Hall, Hall in Tirol, Austria.
August ZaberniggInnere Medizin II, Bezirkskrankenhaus Kufstein, Kufstein, Austria.
Emília FlochováDepartment of Hematology and Transfusion, University Hospital Martin, Martin, Slovakia.
Stanislav PalášthyDepartment of Clinical Hematology, FNsP, J A Reimana Prešov, Prešov, Slovakia.
Olga StehlíkováFaculty of Medicine and CEITEC, University Hospital Brno, Brno, Czech Republic.
Michael DoubekFaculty of Medicine and CEITEC, University Hospital Brno, Brno, Czech Republic.
Petra AltenhoferThird Medical Department, Paracelsus Medical University Salzburg, Salzburg, Austria.
Lukas WeissThird Medical Department, Paracelsus Medical University Salzburg, Salzburg, Austria.
Teresa MagnesThird Medical Department, Paracelsus Medical University Salzburg, Salzburg, Austria.
Lisa PleyerThird Medical Department, Paracelsus Medical University Salzburg, Salzburg, Austria.
Anton KlinglerAssign Data Management and Biostatistics GmbH, Innsbruck, Austria.
Jiří MayerFaculty of Medicine and CEITEC, University Hospital Brno, Brno, Czech Republic.
Richard GreilThird Medical Department, Paracelsus Medical University Salzburg, Salzburg, Austria.ORCID 0000-0002-4462-3694
University of Salzburg · ATCentral European Institute of Technology · CZCharles University · CZKepler Universitätsklinikum · ATData Management (Italy) · ITEngineering Software Steyr (Austria) · ATHanusch Hospital · ATInnsbruck Medical University · ATInstitutul Regional de Oncologie · ROKarl Landsteiner University of Health Sciences · ATKlinikum Wels-Grieskirchen · ATKrankenhaus der Elisabethinen · ATMartin University Hospital · SKMedical University of Vienna · ATMedical University Plovdiv · BGMilitary Medical Academy · BGNational Cancer Research Institute · GBNational Institute of Cardiovascular Diseases · SKQueen Giovanna Hospital · BGSlovak Medical University · SK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

No data are available regarding obesity and outcome in Chronic Lymphocytic Leukemia (CLL). We analyzed 263 patients from the AGMT CLL-8a Mabtenance trial for the impact of obesity. The trial included patients after rituximab-containing induction treatment in first or second line that had achieved at least a PR. A randomization to rituximab maintenance treatment (375 mg/m

Indexed as

AdultAgedAged, 80 and overFemaleHumansLeukemia, Lymphocytic, Chronic, B-CellMaintenance ChemotherapyMaleMiddle AgedObesityPrognosisRituximabSurvival AnalysisTreatment OutcomeRituximabBMICLLmaintenanceobesityrituximab

Identifiers

PMID30888118
PMCPMC6488104
OpenAlexW2924380501

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.