ArticleNeurosurgery2019
Open Resection versus Laser Interstitial Thermal Therapy for the Treatment of Pediatric Insular Epilepsy.
Article in Neurosurgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Predictors of outcomes after surgery for medically intractable insular epilepsy: A systematic review and individual participant data meta-analysis.Epilepsia open · 2023Pooled it
- Recent Advances in the Management of Seizures in Children.Paediatric drugs · 2026Review
- Magnetic Resonance-guided Laser interstitial thermal therapy (MR-gLiTT) in Pediatric Neurosurgery: italian perspective and literature review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Multiple subpial transections with concomitant responsive neurostimulation of the insula: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Motor Outcome After Posterior Insular Resection for Pediatric Epilepsy.Brain sciences · 2025Article
- Stereoelectroencephalography (SEEG)-guided insula resections: is it "Reily" worth it?Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Outcomes of stereoelectroencephalography following failed epilepsy surgery in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Magnetic resonance imaging-guided stereotactic laser ablation therapy for the treatment of pediatric epilepsy: a retrospective multiinstitutional study.Journal of neurosurgery. Pediatrics · 2023Article
- Stereotactic laser interstitial thermal therapy for the treatment of pediatric drug-resistant epilepsy: indications, techniques, and safety.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Knowledge Atlas of Insular Epilepsy: A Bibliometric Analysis.Neuropsychiatric disease and treatment · 2022Article
- Laser interstitial thermal therapy for the treatment of insular lesions: A systematic review.Frontiers in neurology · 2022Article
- Drug resistant epilepsy of the insular lobe: A review and update article.Surgical neurology international · 2022Review
- The utility of diffusion tractography for speech preservation in laser ablation of the dominant insula: illustrative case.Journal of neurosurgery. Case lessons · 2021Article
- Magnetic Resonance-Guided Laser Interstitial Thermal Therapy (MR-gLiTT) in Pediatric Epilepsy Surgery: State of the Art and Presentation of Giannina Gaslini Children's Hospital (Genoa, Italy) Series.Frontiers in neurology · 2021Article
- Epilepsy surgery in tuberous sclerosis complex (TSC): emerging techniques and redefinition of treatment goals.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Stereotactic MRI-guided laser interstitial thermal therapy for extratemporal lobe epilepsy.Epilepsia · 2020Article
- The intersection between immunotherapy and laser interstitial thermal therapy: a multipronged future of neuro-oncology.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2020Review
- Highly realistic simulation for robot-assisted hypothalamic hamartoma real-time MRI-guided laser interstitial thermal therapy (LITT).Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- How technology is driving the landscape of epilepsy surgery.Epilepsia · 2020Review
- Indications, Techniques, and Outcomes of Robot-Assisted Insular Stereo-Electro-Encephalography: A Review.Frontiers in neurology · 2020Review
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundVarious studies suggest that the insular cortex may play an underappreciated role in pediatric frontotemporal/parietal epilepsy. Here, we report on the postsurgical outcomes in 26 pediatric patients with confirmed insular involvement by depth electrode monitoring.
objectiveTo describe one of the largest series of pediatric patients with medically refractory epilepsy undergoing laser interstitial thermal therapy (LITT) or surgical resection of at least some portion of the insular cortex.
methodsPediatric patients in whom invasive insular sampling confirmed insular involvement and who subsequently underwent a second stage surgery (LITT or open resection) were included. Complications and Engel Class outcomes at least 1 yr postsurgery were compiled as well as pathology results in the open surgical cases.
resultsThe average age in our cohort was 10.3 yr, 58% were male, and the average length of follow-up was 2.43 ± 0.20 (SEM) yr. A total of 14 patients underwent LITT, whereas 12 patients underwent open resection. Complications in patients undergoing either LITT or open resection were mostly minimal and generally transient. Forty-three percent of patients who underwent LITT were Engel Class I, compared to 50% of patients who underwent open insular resection.
conclusionBoth surgical resection and LITT are valid management options in the treatment of medically refractory insular/opercular epilepsy in children. Although LITT may be a less invasive alternative to craniotomy, further studies are needed to determine its noninferiority in terms of complication rates and seizure freedom, especially in cases of cortical dysplasia that may involve extensive regions of the brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.