Evidence map›Paper›PMID 30887698›Full record

ArticleJournal of cellular and molecular medicine2019

circEPSTI1 regulates ovarian cancer progression via decoying miR-942.

Jing Xie, Shufen Wang, Genlin Li, Xia Zhao, Feng Jiang, Jie Liu, Weige Tan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 63 citations in OpenAlex.

  1. CircTEC Inhibits the Follicular Atresia in Buffalo (International journal of molecular sciences · 2024
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. CircRNA circ_0000554 promotes ovarian cancer invasion and proliferation by regulating miR-567.Environmental science and pollution research international · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jing XieDepartment of Gynaecology and Obstetrics, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.
Shufen WangDepartment of Gynaecology and Obstetrics, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.
Genlin LiDepartment of Gynaecology and Obstetrics, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.
Xia ZhaoDepartment of Gynaecology and Obstetrics, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.
Feng JiangDepartment of Gynaecology and Obstetrics, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.
Jie LiuDepartment of Gynaecology and Obstetrics, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.
Weige TanBreast Surgery Department, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.ORCID 0000-0001-8633-1692
First Affiliated Hospital of University of South China · CNFirst Affiliated Hospital of Guangzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing studies show that circular RNAs (circRNAs) play vital roles in tumour progression. But, how circRNAs function in ovarian cancer is mostly unclear. Here, we detected the expression of circEPSTI1 in ovarian cancer and explored the function of circEPSTI1 in ovarian cancer via a series of experiments. Then, we performed luciferase assay and RNA immunoprecipitation (RIP) assay to explore the competing endogenous RNA (ceRNA) function of circEPSTI1 in ovarian cancer. qRT-PCR verified that circEPSTI1 was overexpressed in ovarian cancer. Inhibition of circEPSTI1 suppressed ovarian cancer cell proliferation, invasion but promoted cell apoptosis. Luciferase assays and RIP assay showed that circEPSTI1 and EPSTI1 (epithelial stromal interaction 1) could directly bind to miR-942. And circEPSTI1 could regulate EPSTI1 expression via sponging miR-942. In summary, circEPSTI1 regulated EPSTI1 expression and ovarian cancer progression by sponging miR-942. circEPSTI1 could be used as a biomarker and therapeutic target in ovarian cancer.

Indexed as

Gene Expression Regulation, NeoplasticAnimalsApoptosisCell Line, TumorCell ProliferationDisease ProgressionFemaleHumansMice, Inbred BALB CMice, NudeMicroRNAsNeoplasm InvasivenessNeoplasm ProteinsOvarian NeoplasmsRNA, CircularRNA InterferenceEPSTI1 protein, humanMicroRNAsMIRN942 microRNA, humanNeoplasm ProteinsRNA, CircularcircEPSTI1circular RNAscompetitive endogenous RNAsEPSTI1miR-942ovarian cancer

Identifiers

PMID30887698
PMCPMC6484424
OpenAlexW2922974208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.