Evidence map›Paper›PMID 30887460›Full record

ArticleJournal of the American Society for Mass Spectrometry2019

Selective Gas-Phase Mass Tagging via Ion/Molecule Reactions Combined with Single Analyzer Neutral Loss Scans to Probe Pharmaceutical Mixtures.

Dalton T Snyder, Lucas J Szalwinski, Alice L Pilo, Nina K Jarrah, R Graham Cooks

Abstract read
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In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dalton T SnyderDepartment of Chemistry, Purdue University, West Lafayette, IN, 47907, USA.
Lucas J SzalwinskiDepartment of Chemistry, Purdue University, West Lafayette, IN, 47907, USA.
Alice L PiloAnalytical Research and Development, Merck & Co., Inc., Rahway, NJ, 07065, USA.
Nina K JarrahAnalytical Research and Development, Merck & Co., Inc., Rahway, NJ, 07065, USA.
R Graham CooksDepartment of Chemistry, Purdue University, West Lafayette, IN, 47907, USA. cooks@purdue.edu.ORCID http://orcid.org/0000-0002-9581-9603

Funding

National Aeronautics and Space Administration NNX16AJ25G
6 · The paper itself

Abstract

We have demonstrated the use of a simple single ion trap mass spectrometer to identify classes of compounds as well as individual components in complex mixtures. First, a neutral reagent was used to mass tag oxygen-containing analytes using a gas-phase ion/molecule reaction. Then, a neutral loss scan was used to indicate the carboxylic acids. The lack of unit mass selectivity in the neutral loss scan required subsequent product ion scans to confirm the presence and identity of the individual carboxylic acids. The neutral loss scan technique reduced the number of data-dependent MS/MS scans required to confirm identification of signals as protonated carboxylic acids. The method was demonstrated on neat mixtures of standard carboxylic acids as well as on solutions of relevant pharmaceutical tablets and may be generalizable to other ion/molecule reactions.

Indexed as

Boronic AcidsCarboxylic AcidsIonsMethylationOxygenPharmaceutical PreparationsProtonsTabletsTandem Mass SpectrometryBoronic AcidsCarboxylic AcidsIonsOxygenPharmaceutical PreparationsProtonsTabletsCarboxylic acidIon/molecule reactionLinear ion trapNeutral loss scan

Identifiers

PMID30887460

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.