Evidence map›Paper›PMID 30887439›Full record

ArticleJournal of general internal medicine2019

A Patient with Sjogren's Syndrome and Subsequent Diagnosis of Inclusion Body Myositis and Light-Chain Amyloidosis.

Jason Hom, Shruti Marwaha, Anna Postolova, Jessie Kittle, Rosaline Vasquez, Jean Davidson, Jennefer Kohler, Annika Dries, Liliana Fernandez-Betancourt, Marta Majcherska and 9 more

Registry-linked trialOpen access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of general internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02450851 (Clinical and Genetic Evaluation of Patients With Undiagnosed Disorders Through the Undiagnosed Diseases Network), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02450851 recruitingnot on this map

Clinical and Genetic Evaluation of Patients With Undiagnosed Disorders Through the Undiagnosed Diseases Network

TypeobservationalSponsorNational Human Genome Research Institute (NHGRI)Ran2015 to 2028Enrolled20,000ConditionsGenetic Disease
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

Jason HomStanford Center for Undiagnosed Diseases, Stanford University School of Medicine, Stanford, CA, USA. jasonhom@stanford.edu.
Shruti MarwahaStanford Center for Undiagnosed Diseases, Stanford University School of Medicine, Stanford, CA, USA.
Anna PostolovaDivision of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA.
Jessie KittleDivision of Hospital Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Rosaline VasquezDivision of Primary Care and Population Health, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Jean DavidsonStanford Center for Undiagnosed Diseases, Stanford University School of Medicine, Stanford, CA, USA.
Jennefer KohlerStanford Center for Undiagnosed Diseases, Stanford University School of Medicine, Stanford, CA, USA.
Annika DriesStanford Center for Undiagnosed Diseases, Stanford University School of Medicine, Stanford, CA, USA.
Liliana Fernandez-BetancourtStanford Center for Undiagnosed Diseases, Stanford University School of Medicine, Stanford, CA, USA.
Marta MajcherskaStanford Center for Undiagnosed Diseases, Stanford University School of Medicine, Stanford, CA, USA.
Joanna DearloveDepartment of Neurology, Stanford University School of Medicine, Stanford, CA, USA.
Shyam RaghavanDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Hannes VogelDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Jonathan A BernsteinStanford Center for Undiagnosed Diseases, Stanford University School of Medicine, Stanford, CA, USA.
Paul FisherStanford Center for Undiagnosed Diseases, Stanford University School of Medicine, Stanford, CA, USA.
Euan AshleyStanford Center for Undiagnosed Diseases, Stanford University School of Medicine, Stanford, CA, USA.
Jacinda SampsonStanford Center for Undiagnosed Diseases, Stanford University School of Medicine, Stanford, CA, USA.
Matthew WheelerStanford Center for Undiagnosed Diseases, Stanford University School of Medicine, Stanford, CA, USA.
Undiagnosed Diseases Network
Stanford University · USStanford Medicine · US

Funding

What comes next? Engaging stakeholders in governance of participant data and relationships during the sunset of large genomic medicine research initiativesU01HG010218 · NHGRI · STANFORD UNIVERSITY · PI ASHLEY, EUAN A, BERNSTEIN, JONATHAN ADAM · 2018 to 2022
$6.3M
NHGRI NIH HHS U01 HG010218
6 · The paper itself

Abstract

We discuss a challenging case of a 58-year-old Vietnamese-American woman who presented to her new primary care provider with an 8-year history of slowly progressive dysphagia, hoarseness, muscle weakness with associated frequent falls, and weight loss. She eventually reported dry eyes and dry mouth, and she was diagnosed with Sjogren's syndrome. Subsequently, she was additionally diagnosed with inclusion body myositis and gastric light-chain (AL) amyloidosis. Although inclusion body myositis has been previously associated with Sjogren's syndrome, inclusion body myositis is rare in non-Caucasians, and the trio of Sjogren's syndrome, inclusion body myositis, and AL amyloidosis has not been previously reported. Sjogren's syndrome is a systemic autoimmune condition characterized by ocular and oral dryness. It is one of the most common rheumatologic disorders in the USA and worldwide. Early diagnosis of Sjogren's is particularly important given the frequency and variety of associated autoimmune diseases and extraglandular manifestations. Furthermore, although inclusion body myositis has a low prevalence, it is the most common inflammatory myopathy in older adults and is unfortunately associated with long delays in diagnosis, so knowledge of this disorder is also crucial for practicing internists.

Indexed as

FemaleHumansImmunoglobulin Light-chain AmyloidosisMiddle AgedMyositis, Inclusion BodySjogren's Syndromeamyloidosisimmunophenotypinginclusion body myositisSjogren’s syndrome

Identifiers

PMID30887439
PMCPMC6544676
OpenAlexW2922144460

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.