ReviewCurrent nutrition reports2019
The Influence of Sedentary Behavior on Cancer Risk: Epidemiologic Evidence and Potential Molecular Mechanisms.
Review in Current nutrition reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Sedentary behavior and risk of chronic kidney disease: a systematic review and meta-analysis.International urology and nephrology · 2025Pooled it
- Association between domain-specific sedentary behaviour and endometrial cancer: a systematic review and meta-analysis.BMJ open · 2023Pooled it
- Sedentary behaviour in relation to ovarian cancer risk: a systematic review and meta-analysis.European journal of epidemiology · 2021Pooled it
- Protective Effect on Mortality of Active Commuting to Work: A Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2020Pooled it
- Accelerometry-measured prolonged and interrupted sedentary behavior and cancer incidence and mortality: A cohort study of 91,292 UK Biobank participants.PLoS medicine · 2026Article
- Sedentary behaviour and cancer risk: a World Cancer Research Fund International Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis.medRxiv : the preprint server for health sciences · 2026Article
- Intervention mapping to develop a patient-advocate enhanced program to reduce sedentary behavior in endometrial cancer survivors.Journal of cancer survivorship : research and practice · 2026Article
- Chronic kidney disease as an active driver of digestive tract tumors: mechanistic insights and emerging management strategies.Frontiers in cell and developmental biology · 2026Review
- Sedentary Time and Breast Cancer Risk in the Sister Study Cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Evolution of the burden of disease for high BMI-associated colorectal cancer, 1990-2021: Global trends, regional heterogeneity, and population risk stratification.Preventive medicine reports · 2025Article
- Deciphering the impact of dietary habits and behavioral patterns on colorectal cancer.International journal of surgery (London, England) · 2025Review
- Burden of cancer attributable to sedentary behaviour in Germany: an epidemiological analysis of survey data.BMJ open · 2025Article
- Machine learning applications in the analysis of sedentary behavior and associated health risks.Frontiers in artificial intelligence · 2025Review
- Review
- Harnessing Artificial Intelligence for the Detection and Management of Colorectal Cancer Treatment.Cancer prevention research (Philadelphia, Pa.) · 2024Review
- Hotspots and trends in health-oriented physical literacy research: a visual analysis based on the WOS database.BMC public health · 2024Article
- A tree-based corpus annotated with Cyber-Syndrome, symptoms, and acupoints.Scientific data · 2024Article
- Dietary Patterns and Lifestyle Factors Associated with the Risk of Colorectal Cancer: A Hospital-Based Case-Control Study among Malaysians.The Malaysian journal of medical sciences : MJMS · 2024Article
- Article
- Association between leisure sedentary behaviour and uterine fibroids in non-menopausal women: a population-based study.BMJ open · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewSedentary behavior is an emerging risk factor for several cancers. Here, we review the current epidemiologic evidence on sedentary behavior and cancer risk and summarize potential underlying molecular mechanisms. RECENT
findingsHigh compared to low sedentary behavior is associated with a 28-44% increased risk of colon cancer, a 8-17% increased risk of breast cancer, and a 28-36% increased risk of endometrial cancer. For other cancer sites, the current evidence is insufficient, mainly due to sparse numbers of available studies. Potential underlying biologic mechanisms linking prolonged sedentary behavior to increased cancer risk include metabolic dysfunction, alterations in circulating levels of sex hormones, and low-grade systemic chronic inflammation. Prolonged sedentary behavior is positively related to cancers of the colon, breast, and endometrium. For other cancer types, the current evidence is inconclusive. Underlying biological mechanisms are poorly understood and need to be an integral part of future research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.