SynthesisReviews in endocrine & metabolic disorders2019
Efficacy of radiofrequency ablation in autonomous functioning thyroid nodules. A systematic review and meta-analysis.
Synthesis in Reviews in endocrine & metabolic disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Ablative Technologies for Thyroid Nodules: A Health Technology Assessment.Ontario health technology assessment series · 2026Pooled it
- Efficacy of thermal ablation in benign non-functioning solid thyroid nodule: A systematic review and meta-analysis.Endocrine · 2020Pooled it
- Efficacy, safety and predictors of response to minimally invasive treatments of the thyroid: a prospective study.Endocrine · 2026Article
- The clinical utility of thermal ablation procedures in thyroid nodules: Latin American Thyroid Society (LATS) surgical affairs committee expert opinion. Part 2.Archives of endocrinology and metabolism · 2025Review
- Predicting the efficacy of microwave ablation of benign thyroid nodules from ultrasound images using deep convolutional neural networks.BMC medical informatics and decision making · 2025Article
- Current guidelines for the application of radiofrequency ablation for thyroid nodules: a narrative review.Gland surgery · 2024Review
- A novel guided approach to radiofrequency ablation of thyroid nodules: the Toronto Sunnybrook experience.Frontiers in endocrinology · 2024Article
- Brazilian Consensus on the Application of Thermal Ablation for Treatment of Thyroid Nodules: A Task Force Statement by the Brazilian Society of Interventional Radiology and Endovascular Surgery (SOBRICE), Brazilian Society of Head and Neck Surgery (SBCCP), and Brazilian Society of Endocrinology and Metabolism (SBEM).Archives of endocrinology and metabolism · 2024Article
- Delayed Cancer Diagnosis in Thyroid Nodules Initially Treated as Benign With Radiofrequency Ablation: Ultrasound Characteristics and Predictors for Cancer.Korean journal of radiology · 2023Article
- 2022 Taiwan clinical multicenter expert consensus and recommendations for thyroid radiofrequency ablation.Ultrasonography (Seoul, Korea) · 2023Article
- Radiofrequency ablation as a novel modality in the USA for treating toxic thyroid nodules: case series and literature review.Gland surgery · 2022Article
- Article
- Image-guided thermal ablation in autonomously functioning thyroid nodules. A retrospective multicenter three-year follow-up study from the Italian Minimally Invasive Treatment of the Thyroid (MITT) Group.European radiology · 2022Article
- Safety and Efficacy of Radiofrequency Ablation of Thyroid Nodules-Expanding Treatment Options in the United States.Journal of the Endocrine Society · 2021Article
- Image Risk Assessment of the Thyroid Cancer Model Based on Discriminant Analysis and the Value of TAP and CEA Combined Detection.Journal of healthcare engineering · 2021Article
- Radiofrequency ablation of benign thyroid nodules: recommendations from the Asian Conference on Tumor Ablation Task Force.Ultrasonography (Seoul, Korea) · 2021Article
- Joint Detection of Tap and CEA Based on Deep Learning Medical Image Segmentation: Risk Prediction of Thyroid Cancer.Journal of healthcare engineering · 2021Article
- Update of Radiofrequency Ablation for Treating Benign and Malignant Thyroid Nodules. The Future Is Now.Frontiers in endocrinology · 2021Review
- Long-Term Outcomes of Thermal Ablation for Benign Thyroid Nodules: The Issue of Regrowth.International journal of endocrinology · 2021Review
- Ultrasound-Guided Thermal Ablation of Thyroid Nodules: Technicalities Progress and Clinical Applications, Especially in Malignant Thyroid Nodules.Frontiers in oncology · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whether thermal ablation is effective to treat toxic thyroid nodules (TTN) is still unknown. Aim of this review was to achieve more robust evidence on the efficacy of radiofrequency ablation (RFA) in treating TTN in terms of TSH normalization, thyroid scintiscan, and volume reduction rate (VRR). A comprehensive literature search of PubMed/Medline and Scopus was performed in November 2018 to retrieve published studies. Original papers reporting TTN treated by RFA and later followed-up were eligible. Excluded were: articles not within this field, articles with unclear data, overlapping series, case/series reports. Discordances were solved in a final collegial meeting. Information was collected concerning population features, treatment procedure, follow-up, cases with TSH normalization, cases with scintiscan normalization, VRR of nodules. Pooled prevalence of patients with TSH or scintiscan normalization, and pooled VRR over time were calculated. For statistical analysis, the random-effects model was used. Eight articles published between 2008 and 2018 were included. The overall number of AFTN treated by RFA was 205. Five studies used a single session of treatment. The time of follow-up ranged from six to 24 months. The pooled rate of patients with TSH normalization was 57%. The pooled rate of patients with scintigraphically proven optimal response was 60%. The pooled VRR at 1 year was 79%. Baseline nodules volume was associated with the rate of TSH normalization. In conclusion, a moderate efficacy of RFA in treating TTN was found, and this can represent a solid starting point in this field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.