ArticleHead and neck pathology2019
Current Challenges in the Staging of Oral Cancer.
Article in Head and neck pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Histopathological parameters reported in microinvasive oral squamous cell carcinoma: a systematic review.Medicina oral, patologia oral y cirugia bucal · 2023Pooled it
- Histopathological Definitions of Extranodal Extension: A Systematic Review.Head and neck pathology · 2021Pooled it
- [Clinical Significance of Extranodal Extension in Non-small Cell Lung Cancer: Current Status and Future Prospects].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2026Review
- Prognosis, Controversies and Assessment of Bone Erosion or Invasion of Oral Squamous Cell Carcinoma.Diagnostics (Basel, Switzerland) · 2025Review
- Traversing the Terrain: Potential Pitfalls within the AJCC 8th Edition Staging System for Lip and Oral Cavity Cancers.Head and neck pathology · 2024Article
- Computed tomography/magnetic resonance imaging for mandibular boundary invasion of oral squamous cell carcinoma assessment.BMC oral health · 2024Article
- Salivary-Based Cell-Free Mitochondrial DNA Level Is an Independent Prognostic Biomarker for Patients with Head and Neck Squamous Cell Carcinoma.Journal of personalized medicine · 2023Article
- Lymph Node Ratio as a Prognostic Factor in Neck Dissection in Oral Cancer Patients: A Systematic Review and Meta-Analysis.Cancers · 2022Review
- New Scenarios in Pharmacological Treatments of Head and Neck Squamous Cell Carcinomas.Cancers · 2021Review
- Impact of extrinsic tongue muscle invasion on stage migration in AJCC 8th edition staging of oral cavity carcinoma.Oral oncology · 2020Article
- Feasibility of Use of the 8Annals of maxillofacial surgeryArticle
Corrections and comments
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Authors and funding
1 author.
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Abstract
In the recently published 8th edition of the AJCC Cancer Staging Manual, new pathological elements are required for the N and T category determinations for oral cavity cancers. This includes determination of depth of tumor invasion and assessment of metastatic lymph nodes for extranodal extension. Although definitions and some guidance are provided for the interpretation of these elements, pathologists frequently encounter ambiguous situations that may result in interobserver and intraobserver variability. Pre-existing staging elements, such as assessment of bone invasion, can also be problematic to interpret. Difficulties in the interpretation of depth of invasion, bone invasion and extranodal invasion are discussed, with examples. Communication with the surgeon, proper specimen orientation, gross examination and sampling are crucial to assessment of these elements. Liberal use of deeper levels and submission of additional sections is suggested. Although general staging guidelines encourage clinicians and pathologists to choose the lower category when there is ambiguity, pathologists may choose to discuss difficulties in the interpretation of specific cases at interdisciplinary tumor boards, to allow a more informed choice of treatment on the part of treating physician and patient. More discussion is required among pathologists to develop specific guidelines for the interpretation of these staging elements.
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