ArticleMolecular biology reports2019
Modulatory effects of Amukkara Choornam on Candida albicans biofilm: in vitro and in vivo study.
Article in Molecular biology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 5 citations in OpenAlex.
- Biological Activity of Cyclic Peptide Extracted fromBiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In the present study, Amukkara Chooram (AC) a well known herbal medicine was investigated for their antibiofilm efficacy against biofilm of Candida albicans. The biofilm inhibitory concentration of 20 µg/mL of AC showed promising effect by inhibiting the biofilm upto 60%. Morphogenic transition state of C. albicans from yeast cells to hyphal transition was prevented by AC was revealed from light microscopic images. In addition, the inhibition of yeast hyphae was examined in the induction medium supplemented with AC. Consequently, atomic force microscope (AFM) also documented the morphological changes observed during the transition state of C. albicans in the presence and absence of AC. Furthermore, scanning electron microscope (SEM) and confocal laser scanning microscopic (CLSM) images showed reduction in the biomass and thickness of the mature biofilm of C. albicans. In vivo investigation of C. albicans with zebrafish infection model presented the clearance of biofilm from the epithelium of the intestinal tissues. Later, the histological changes in liver and kidney due to C. albicans infection open up that treatment with AC was able to significantly rejuvenate the tissues. Altogether, the study presents AC as potent antibiofilm agent with potential ability as alternative medicine to treat C. albicans biofilm mediated infections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.