Evidence map›Paper›PMID 30887171›Full record

ArticleJournal of biomolecular NMR2019

Malene V Christensen, Kenneth T Kongstad, Teis Esben Sondergaard, Dan Staerk, Hanne M Nielsen, Henrik Franzyk, Reinhard Wimmer

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of biomolecular NMR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Malene V ChristensenDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 162, 2100, Copenhagen, Denmark.
Kenneth T KongstadDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 162, 2100, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-4487-7886
Teis Esben SondergaardSection for Biotechnology, Department of Chemistry and Bioscience, Aalborg University, Frederik Bajers Vej 7H, 9220, Aalborg, Denmark.ORCID http://orcid.org/0000-0002-4455-7498
Dan StaerkDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 162, 2100, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-0074-298X
Hanne M NielsenDepartment of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-7285-9100
Henrik FranzykDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 162, 2100, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-2822-1927
Reinhard WimmerSection for Biotechnology, Department of Chemistry and Bioscience, Aalborg University, Frederik Bajers Vej 7H, 9220, Aalborg, Denmark. rw@bio.aau.dk.ORCID http://orcid.org/0000-0001-6942-5056
University of Copenhagen · DKAalborg University · DK

Funding

Natur og Univers, Det Frie Forskningsråd 1323-00344Novo Nordisk Fonden NNF15OC0016186Teknologi og Produktion, Det Frie Forskningsråd 4005-00455
6 · The paper itself

Abstract

Current methods for assessment of cellular uptake of cell-penetrating peptides (CPPs) often rely on detection of fluorophore-labeled CPPs. However, introduction of the fluorescent probe often confers changed physicochemical properties, so that the fluorophore-CPP conjugate may exhibit cytotoxic effects and membrane damage not exerted by the native CPP. In the present study, introduction of fluorine probes was investigated as an alternative to fluorophore labeling of a CPP, since this only confers minor changes to its overall physicochemical properties. The high sensitivity of

Indexed as

FluorineNuclear Magnetic Resonance, BiomolecularAmino AcidsAmino Acid SequenceCaco-2 CellsCell-Penetrating PeptidesHumansModels, MolecularProtein ConformationAmino AcidsCell-Penetrating PeptidesFluorinepenetratin19F labeling19F NMRCell-penetrating peptidesDegradation and uptakePenetratin

Identifiers

PMID30887171
OpenAlexW2920929341

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.