Evidence map›Paper›PMID 30887157›Full record

ArticleThe European journal of health economics : HEPAC : health economics in prevention and care2019

Health state utilities associated with post-surgical Staphylococcus aureus infections.

Louis S Matza, Katherine J Kim, Holly Yu, Katherine A Belden, Antonia F Chen, Mark Kurd, Bruce Y Lee, Jason Webb

Abstract read
In one paragraph

Article in The European journal of health economics : HEPAC : health economics in prevention and care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Health state utilities associated with invasive pneumococcal disease, pneumonia, and recurrent acute otitis media in young children.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Louis S MatzaEvidera, 7101 Wisconsin Avenue, Suite 1400, Bethesda, MD, 20814, USA. louis.matza@evidera.com.
Katherine J KimEvidera, 7101 Wisconsin Avenue, Suite 1400, Bethesda, MD, 20814, USA.
Holly YuPfizer Inc, Collegeville, PA, USA.
Katherine A BeldenSydney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Antonia F ChenDepartment of Orthopaedics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Mark KurdDepartment of Orthopedic Surgery Sidney Kimmel Medical College, Thomas Jefferson University The Rothman Institute, Philadelphia, PA, USA.
Bruce Y LeeJohns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Jason WebbAvon Orthopaedic Centre, Southmead Hospital, Bristol, UK.

Funding

Pfizer EVA-16927
6 · The paper itself

Abstract

introductionSurgical site infections (SSIs) are among the most common and potentially serious complications after surgery. Staphylococcus aureus is a virulent pathogen frequently identified as a cause of SSI. As vaccines and other infection control measures are developed to reduce SSI risk, cost-utility analyses (CUA) of these interventions are needed to inform resource allocation decisions. A recent systematic review found that available SSI utilities are of "questionable quality." Therefore, the purpose of this study was to estimate the disutility (i.e., utility decrease) associated with SSIs.

methodsIn time trade-off interviews, general population participants in the UK (London, Edinburgh) valued health states drafted based on literature and clinician interviews. Health states described either joint or spine surgery, with or without an SSI. The utility difference between otherwise identical health states with and without the SSI represented the disutility associated with the SSI.

resultsA total of 201 participants completed interviews (50.2% female; mean age = 46.2 years). Mean (SD) utilities of health states describing joint and spine surgery without infections were 0.79 (0.23) and 0.78 (0.23). Disutilities of SSIs ranged from - 0.03 to - 0.32, depending on severity of the infection and subsequent medical interventions. All differences between corresponding health with and without SSIs were statistically significant (all p < 0.001).

conclusionThe preference-based SSI disutilities derived in this study may be used to represent mild and serious SSIs in CUAs assessing and comparing the value of vaccinations that may reduce the risk of SSIs.

Indexed as

AdultAnti-Bacterial AgentsFemaleHipHumansInterviews as TopicKneeMaleMiddle AgedPilot ProjectsSpineStaphylococcal InfectionsStaphylococcus aureusSurgical Wound InfectionUnited KingdomAnti-Bacterial AgentsSSIStaphylococcus aureusSurgerySurgical site infectionTime trade-offUtility

Identifiers

PMID30887157
PMCPMC6652168

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.