Evidence map›Paper›PMID 30887138›Full record

ArticleThe AAPS journal2019

Theoretical Considerations for Direct Translation of Unbound Liver-to-Plasma Partition Coefficient from In Vitro to In Vivo.

Zhenhong Li, Li Di, Tristan S Maurer

Abstract read
PubMed Publisher
In one paragraph

Article in The AAPS journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Consideration of the Unbound Drug Concentration in Enzyme Kinetics.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  4. Article
  5. Article
  6. Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities.Drug metabolism and disposition: the biological fate of chemicals · 2019
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zhenhong LiMedicine Design Modeling and Simulation, Pfizer Inc., 1 Portland St. Pfizer, Cambridge, Massachusetts, 02139, USA. zhenhong.li@pfizer.com.
Li DiPharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut, USA.
Tristan S MaurerMedicine Design Modeling and Simulation, Pfizer Inc., 1 Portland St. Pfizer, Cambridge, Massachusetts, 02139, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is considerable interest in developing methods to predict the asymmetric distribution of unbound drug into tissues. The liver is of particular interest due to the multitude of expressed transporters with potential implications for pharmacokinetics, pharmacodynamics, and toxicology. Empirical correlations of in vitro unbound hepatocyte-to-media partition coefficient (in vitro K

Indexed as

Models, BiologicalAnimalsCell LineHepatocytesHumansLiverPermeabilityPlasmaRatsTissue Distributionextended clearance modelfive-compartment modelIVIVEK puuparallel tube model

Identifiers

PMID30887138

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.