Evidence map›Paper›PMID 30887033›Full record

ArticleThe Journal of infectious diseases2020

The Costs of Drugs in Infectious Diseases: Branded, Generics, and Why We Should Care.

Sydney Costantini, Rochelle P Walensky

Abstract read
PubMed Publisher
In one paragraph

Article in The Journal of infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Drug Costs: What Can Infectious Diseases Physicians Do?The Journal of infectious diseases · 2020
    Article
  6. Cost burden of diffuse large B-cell lymphoma.Expert review of pharmacoeconomics & outcomes research · 2019
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Sydney CostantiniMedical Practice Evaluation Center, Massachusetts General Hospital, Boston.
Rochelle P WalenskyMedical Practice Evaluation Center, Massachusetts General Hospital, Boston.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While health care providers have largely turned a blind eye, the cost of health care in the US has been skyrocketing, in part as a result of rising drug prices. Patent protections and market exclusivity, while serving to incentivize targeted new drug development, have exacerbated inequitable outcomes and reduced access, sometimes fueling national epidemics. Branded drug manufacturers face few barriers to exorbitant pricing of drugs with exclusivity-as in the cases of Sovaldi, Zyvox, and Truvada. Furthermore, albendazole, pyrimethamine, and penicillin demonstrate that generic medications without patent exclusivity are not guaranteed to have durably low costs, especially where manufacturer competition is lacking. There is a way forward: through education and awareness, cost-conscious guideline development, government regulation, and market-level incentives, health care providers can collaborate to contain drug prices, curbing expenditures overall while expanding health care access to patients.

Indexed as

Drug CostsAlbendazoleCommunicable DiseasesCosts and Cost AnalysisDrug IndustryDrugs, GenericEmtricitabine, Tenofovir Disoproxil Fumarate Drug CombinationGovernment RegulationHealth ExpendituresHumansLinezolidPenicillinsPyrimethamineSofosbuvirAlbendazoleDrugs, GenericEmtricitabine, Tenofovir Disoproxil Fumarate Drug CombinationLinezolidPenicillinsPyrimethamineSofosbuvirbrandeddrug costsgenerichepatitis CHIVinfectious diseases

Identifiers

PMID30887033

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.