Evidence map›Paper›PMID 30887001›Full record

ArticleHemaSphere2018

Increased Red Cell KCNN4 Activity in Sporadic Hereditary Xerocytosis Associated With Enhanced Single Channel Pressure Sensitivity of PIEZO1 Mutant V598M.

Radhakrishnan Gnanasambandam, Alicia Rivera, David H Vandorpe, Boris E Shmukler, Carlo Brugnara, L Michael Snyder, Immacolata Andolfo, Achille Iolascon, Paulo A Silveira, Nelson Hamerschlak and 2 more

Open access · goldAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in HemaSphere, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 4 countries.

Radhakrishnan GnanasambandamDepartment of Physiology and Biophysics, University of Buffalo, Buffalo, NY, USA.
Alicia RiveraDivision of Nephrology and Vascular Biology Research Center, Beth Israel Deaconess Medical Center, Boston, MA, USA.
David H VandorpeDivision of Nephrology and Vascular Biology Research Center, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Boris E ShmuklerDivision of Nephrology and Vascular Biology Research Center, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Carlo BrugnaraDepartment of Laboratory Medicine, Boston Children's Hospital, Boston, MA, USA.
L Michael SnyderQUEST Diagnostics Inc, Marlborough, MA, USA.
Immacolata AndolfoDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, CEINGE Advanced Biotechnologies, Naples, Italy.
Achille IolasconDepartment of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, CEINGE Advanced Biotechnologies, Naples, Italy.
Paulo A SilveiraDepartment of Hematology, Hospital Israelita Albert Einstein, Sao Paulo, SP, Brazil.
Nelson HamerschlakDepartment of Hematology, Hospital Israelita Albert Einstein, Sao Paulo, SP, Brazil.
Philip GottliebDepartment of Physiology and Biophysics, University of Buffalo, Buffalo, NY, USA.
Seth L AlperDivision of Nephrology and Vascular Biology Research Center, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Harvard University · USHospital Israelita Albert Einstein · BRUniversity at Buffalo, State University of New York · USBeth Israel Deaconess Medical Center · USBoston Children's Hospital · USFederico II University Hospital · ITQuest Diagnostics (United States) · USUniversity of Naples Federico II · IT

Funding

Mechanosensitive ion channels and cortical mechanicsR01HL054887 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI SACHS, FREDERICK · 1995 to 2016
$9.6M
NHLBI NIH HHS R01 HL054887
6 · The paper itself

Abstract

Supplemental Digital Content is available in the text.

Identifiers

PMID30887001
PMCPMC6407803
OpenAlexW2808132394

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.