ArticleBMC rheumatology2018
Trends in incidence, mortality, and causes of death associated with systemic sclerosis in Denmark between 1995 and 2015: a nationwide cohort study.
Article in BMC rheumatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Mortality in Inflammatory Rheumatic Diseases: Lithuanian National Registry Data and Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Incidence and prevalence of systemic sclerosis globally: a comprehensive systematic review and meta-analysis.Rheumatology (Oxford, England) · 2021Pooled it
- Advancing drug development for systemic sclerosis by prioritizing findings from human genetic association studies.Rheumatology (Oxford, England) · 2026Review
- Acute Heart Failure in Advanced Systemic Sclerosis With Multiorgan Involvement.Case reports in cardiology · 2026Article
- [S2k guidelines on diagnostics and treatment of systemic sclerosis : Full version].Zeitschrift fur Rheumatologie · 2025Review
- Occupational history of psychosocial work environment exposures and risk of autoimmune rheumatic diseases - a Danish register-based cohort study.Scandinavian journal of work, environment & health · 2025Article
- A scoping review of the epidemiology of systemic sclerosis and its organ manifestations: 2018-2024.Current opinion in rheumatology · 2025Article
- EPIDEMIOLOGICAL PROFILE OF PATIENTS WITH SYSTEMIC SCLEROSIS TREATED AT A QUATERNARY HOSPITAL IN THE STATE OF SÃO PAULO.Acta ortopedica brasileira · 2025Article
- Epidemiology of systemic sclerosis in Quebec, Canada: a population-based study.Lancet regional health. Americas · 2024Article
- Steady decrease in systemic sclerosis mortality rates at younger ages over the past five decades.Rheumatology (Oxford, England) · 2024Article
- Direct and indirect costs of systemic sclerosis and associated interstitial lung disease: A nationwide population-based cohort study.Respirology (Carlton, Vic.) · 2022Article
- Interstitial Lung Disease in Connective Tissue Diseases: Survival Patterns in a Population-Based Cohort.Journal of clinical medicine · 2021Article
- CHLD score, a new score based on traditional risk factor evaluation and long-term cardiovascular outcomes in patients with systemic sclerosis.Scientific reports · 2021Article
- Epidemiology of systemic sclerosis: a multi-database population-based study in Tuscany (Italy).Orphanet journal of rare diseases · 2021Article
- Overall mortality.Journal of scleroderma and related disorders · 2021Article
- Epidemiological profile of systemic sclerosis in the southeast region of Romania.Experimental and therapeutic medicine · 2021Article
- Incidence, prevalence and mortality of systemic sclerosis in Italy: a nationwide population-based study using administrative health data.Rheumatology international · 2021Article
- Association of soluble urokinase plasminogen activator receptor levels with fibrotic and vascular manifestations in systemic sclerosis.PloS one · 2021Article
- Economic Burden and Management of Systemic Sclerosis-Associated Interstitial Lung Disease in 8 European Countries: The BUILDup Delphi Consensus Study.Advances in therapy · 2021Article
- Dynamics of digital ulcers in systemic sclerosis.Experimental and therapeutic medicine · 2020Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate the incidence and the mortality-rates of systemic sclerosis (SSc), its primary causes of death, and the temporal trends in events in Denmark during the last decades.
methodsUsing the Danish National Patient Registry, we identified all persons aged ≥18 years with a first-time diagnosis of SSc (ICD-10 code M34, excluding M34.2) between 1995 and 2015.
resultsA total of 2778 incident SSc cases were identified. The mean age at time of SSc diagnosis was 56 (standard deviation 15) years and 76% were women. The overall incidence rate (per 1,000,000 person-years) of diagnosed SSc was 24.4 (95% confidence interval 23.6-25.4), with a slight increase over the study period, age- and sex-adjusted incidence rate ratio 1.02 (95% confidence interval 1.01-1.02) per 1-year increase. The 1-year all-cause mortality rate per 100 person-years decreased from 6.1 (3.1-12.2) in 1995 to 5.3 (2.5-11.1) in 2015, sex- and age-adjusted hazard ratio 0.96 (95% CI 0.94-0.98) per 1-year increase. Over the period, the average age at SSc diagnosis increased and the proportion of women decreased, whereas the burden of comorbidities increased. One fifth of all deaths were attributable to cardiovascular causes, a fourth to pulmonary diseases, and 15% were due to cancer.
conclusionsWithin the last few decades, the incidence of SSc has increased and the 1-year mortality rate has decreased slightly in Denmark. Almost half of all deaths were attributable to cardiopulmonary causes.
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