ArticleBMC rheumatology2018
The role of vitamin D testing and replacement in fibromyalgia: a systematic literature review.
Article in BMC rheumatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Relationship Between Serum Vitamin D Levels and Chronic Musculoskeletal Pain in Adults: A Systematic Review.Nutrients · 2024Pooled it
- The Efficacy of Vitamin D Supplementation in the Treatment of Fibromyalgia Syndrome and Chronic Musculoskeletal Pain.Nutrients · 2022Pooled it
- Efficacy and safety of weekly vitamin DClinical rheumatology · 2021Trial
- Trial
- Chronic cholecalciferol supplementation and adequate vitamin D status are associated with reduced risk of Long COVID.Journal of endocrinological investigation · 2026Article
- Why Fibromyalgia Criteria Keep Changing: A Systematic Review of Misclassification, Measurement, and Diagnostic Spillover.Archives of rheumatology · 2026Article
- A three-stage family medicine approach to unmasking vitamin D deficiency in a post-COVID-19 prediabetes patient.Journal of family medicine and primary care · 2026Article
- "Problem of pain": Further questions for the utility of vitamin D for chronic pain after gastrointestinal surgery.World journal of gastrointestinal surgery · 2026Article
- Vitamin D in the elderly: the phil-rouge in preventing bone, muscle and adipose deterioration?Archives of endocrinology and metabolism · 2025Review
- Common Non-Rheumatic Medical Conditions Mimicking Fibromyalgia: A Simple Framework for Differential Diagnosis.Diagnostics (Basel, Switzerland) · 2024Review
- Review
- Vitamin D status and clinical implications in the adult population of Malaysia: a position paper by the Malaysian Vitamin D Special Interest Group.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Review
- Low Vitamin D Levels Are Associated With Long COVID Syndrome in COVID-19 Survivors.The Journal of clinical endocrinology and metabolism · 2023Article
- Pain Biomarkers in Fibromyalgia Syndrome: Current Understanding and Future Directions.International journal of molecular sciences · 2023Review
- Psychological Outcomes and Quality of Life of Fibromyalgia Patients with Vitamin D Supplementation-A Meta-Analysis.Journal of clinical medicine · 2023Review
- Article
- Association of Vitamin B12, Vitamin D, and Thyroid-Stimulating Hormone With Fatigue and Neurologic Symptoms in Patients With Fibromyalgia.Mayo Clinic proceedings. Innovations, quality & outcomes · 2022Article
- Can the Combination of Rehabilitation and Vitamin D Supplementation Improve Fibromyalgia Symptoms at All Ages?Journal of functional morphology and kinesiology · 2022Article
- Evaluation of clinical relationship of serum niacin and dopamine levels in patients with fibromyalgia syndrome.Turkish journal of physical medicine and rehabilitation · 2022Article
- The Role of Nutrient Supplementation in the Management of Chronic Pain in Fibromyalgia: A Narrative Review.Pain and therapy · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFibromyalgia is a debilitating condition, characterized by extensive muscular pain and fatigue. Vitamin D is essential for overall health, with ubiquitous involvement in various inflammatory and pain pathways. Little is known about its role in fibromyalgia. We performed a systematic literature review to determine if vitamin D contributes to the pathology and disability of patients with fibromyalgia, and to assess the role of vitamin D supplementation in disease management.
methodsWe searched Medline, EMBASE and the Cochrane Library for clinical studies and randomized controlled trials published in English during January 2000 to June 2017, using the terms vitamin D or hypovitaminosis D combined with fibromyalgia or FMS. References were reviewed manually and articles were only included if they were specific in their diagnosis of fibromyalgia and used appropriate control groups.
resultsFour hundred and sixty-six studies were retrieved, of which fourteen fulfilled the inclusion criteria. Six studies, of which two had the best quality evidence, found that patients with fibromyalgia have low levels of vitamin D compared to healthy controls. Conflicting results were obtained on the effect of vitamin D on pain or symptom control, with no clear consensus as to the role of supplementation in the management of fibromyalgia.
conclusionsOur results highlight an association between vitamin D deficiency and fibromyalgia. However, its role in the pathophysiology of fibromyalgia and the clinical relevance of identifying and treating this requires further elucidation with appropriately controlled studies.
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Registered trials
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