Evidence map›Paper›PMID 30886977›Full record

ArticleBMC rheumatology2018

Resveratrol displays anti-inflammatory properties in an ex vivo model of immune mediated inflammatory arthritis.

S Lomholt, A Mellemkjaer, M B Iversen, S B Pedersen, T W Kragstrup

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC rheumatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Molecular insights into phytochemicals exhibiting anti-arthritic activity: systematic review : John Di Battista.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

S Lomholt1Department of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0001-5916-4219
A Mellemkjaer1Department of Biomedicine, Aarhus University, Aarhus, Denmark.
M B Iversen1Department of Biomedicine, Aarhus University, Aarhus, Denmark.
S B Pedersen2Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
T W Kragstrup1Department of Biomedicine, Aarhus University, Aarhus, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundResveratrol is a natural polyphenol found in berries, roots and wine that is well known to have anti-inflammatory and anti-oxidative properties. The anti-inflammatory effect has been reported for both immune cells and connective tissues, but only few studies have investigated effects on immune mediated inflammatory arthritis. None of which have studied this effect when combining resveratrol with methotrexate or adalimumab, two major drugs in the treatment of immune mediated inflammatory arthritis.We therefore aimed to investigate the anti-inflammatory effect of resveratrol alone and in combination with methotrexate or adalimumab in ex vivo models of immune mediated inflammatory arthritis. We furthermore aimed to describe any variations in this effect based on disease activity and cellular composition of the synovial fluid infiltrate.

methodsSynovial fluid mononuclear cells from patients with rheumatoid arthritis (

resultsResveratrol reduced monocyte chemoattractant protein 1 production by synovial fluid mononuclear cells significantly (

conclusionResveratrol has anti-inflammatory properties in our ex vivo model of immune mediated inflammatory arthritis. Results show an additive effect of resveratrol, when combined with methotrexate in samples dominated by lymphocytes and samples from patients with low disease activity. This suggests further investigations in vitro and whether this effect may also be present in a clinical setting.

Indexed as

Anti-inflammatory agentsLow disease activityMCP-1MethotrexateMonocyte chemoattractant protein 1ResveratrolRheumatoid arthritisSpondyloarthritis

Identifiers

PMID30886977
PMCPMC6390607

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.