Evidence map›Paper›PMID 30886848›Full record

ReviewFrontiers in cell and developmental biology2019

Expanding the CRISPR Toolbox in Zebrafish for Studying Development and Disease.

Kaili Liu, Cassidy Petree, Teresa Requena, Pratishtha Varshney, Gaurav K Varshney

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 1 synthesis or guideline pooled it, 129 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Advances in CRISPR-Cas9 in lineage tracing of model animals.Animal models and experimental medicine · 2025
    Review
  4. Review
  5. Review
  6. The zebrafish (NAR genomics and bioinformatics · 2025
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kaili LiuFunctional and Chemical Genomics Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.
Cassidy PetreeFunctional and Chemical Genomics Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.
Teresa RequenaFunctional and Chemical Genomics Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.
Pratishtha VarshneyFunctional and Chemical Genomics Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.
Gaurav K VarshneyFunctional and Chemical Genomics Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.
Oklahoma Medical Research Foundation · US

Funding

Understanding connective tissue development and disease with PDGFR-driven..... P20GM103636 · NIGMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI THOMPSON, LINDA F · 2013 to 2023
$26.9M
NIGMS NIH HHS P20 GM103636
6 · The paper itself

Abstract

The study of model organisms has revolutionized our understanding of the mechanisms underlying normal development, adult homeostasis, and human disease. Much of what we know about gene function in model organisms (and its application to humans) has come from gene knockouts: the ability to show analogous phenotypes upon gene inactivation in animal models. The zebrafish (

Indexed as

base editorsCas12a (Cpf1)CRISPR/Cas9disease modelslineage tracingzebrafish

Identifiers

PMID30886848
PMCPMC6409501
OpenAlexW2918368935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.