ArticleLight, science & applications2019
Optical force-induced nonlinearity and self-guiding of light in human red blood cell suspensions.
Article in Light, science & applications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 67 citations in OpenAlex.
- Red Blood Cells as Endogenous Biotweezers for Optical Micromanipulation In Vivo.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Laser speckle particle sizer (SPARSE) informs the size distribution of tissue granularities.Science advances · 2025Article
- Optically Programmable Living Microrouter in Vivo.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Hypothermal opto-thermophoretic tweezers.Nature communications · 2023Article
- Extreme transport of light in spheroids of tumor cells.Nature communications · 2023Article
- Hypothermal opto-thermophoretic tweezers.Research square · 2023Article
- Conservation of orbital angular momentum and polarization through biological waveguides.Scientific reports · 2022Article
- Nonlinear thermal lensing of high repetition rate ultrafast laser light in plasmonic nano-colloids.Nanophotonics (Berlin, Germany) · 2022Article
- Biophotonic probes for bio-detection and imaging.Light, science & applications · 2021Review
Corrections and comments
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Authors and funding
15 authors at 10 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osmotic conditions play an important role in the cell properties of human red blood cells (RBCs), which are crucial for the pathological analysis of some blood diseases such as malaria. Over the past decades, numerous efforts have mainly focused on the study of the RBC biomechanical properties that arise from the unique deformability of erythrocytes. Here, we demonstrate nonlinear optical effects from human RBCs suspended in different osmotic solutions. Specifically, we observe self-trapping and scattering-resistant nonlinear propagation of a laser beam through RBC suspensions under all three osmotic conditions, where the strength of the optical nonlinearity increases with osmotic pressure on the cells. This tunable nonlinearity is attributed to optical forces, particularly the forward-scattering and gradient forces. Interestingly, in aged blood samples (with lysed cells), a notably different nonlinear behavior is observed due to the presence of free hemoglobin. We use a theoretical model with an optical force-mediated nonlocal nonlinearity to explain the experimental observations. Our work on light self-guiding through scattering bio-soft-matter may introduce new photonic tools for noninvasive biomedical imaging and medical diagnosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.