Evidence map›Paper›PMID 30886672›Full record

ArticleOxidative medicine and cellular longevity2019

Nitric Oxide Influences HSV-1-Induced Neuroinflammation.

Joanna Cymerys, Andrzej Kowalczyk, Katarzyna Mikołajewicz, Anna Słońska, Małgorzata Krzyżowska

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  4. Review
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  8. Article
  9. Review
  10. Article
  11. Neuroinflammation in neurodegenerationFrontiers in immunology · 2022
    Review
  12. Review
  13. Viral Involvement in Alzheimer's Disease.ACS chemical neuroscience · 2021
    Article
  14. Article
  15. Review
  16. Article
  17. Article
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  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Joanna CymerysDepartment of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8, 02-786 Warsaw, Poland.
Andrzej KowalczykPORT Polish Center for Technology Development, Stablowicka 147, 54-066 Wroclaw, Poland.
Katarzyna MikołajewiczPORT Polish Center for Technology Development, Stablowicka 147, 54-066 Wroclaw, Poland.
Anna SłońskaDepartment of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8, 02-786 Warsaw, Poland.
Małgorzata KrzyżowskaPORT Polish Center for Technology Development, Stablowicka 147, 54-066 Wroclaw, Poland.ORCID 0000-0002-8409-3974
Łukasiewicz Research Network – PORT Polish Center for Technology Development · PLWarsaw University of Life Sciences · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herpes simplex virus type 1 (HSV-1) has the ability to replicate in neurons and glial cells and to produce encephalitis leading to neurodegeneration. Accumulated evidence suggests that nitric oxide (NO) is a key molecule in the pathogenesis of neurotropic virus infections. NO can exert both cytoprotective as well as cytotoxic effects in the central nervous system (CNS) depending on its concentration, time course exposure, and site of action. In this study, we used an

Indexed as

Amyloid beta-PeptidesAnimalsCell DeathCell LineChemokinesChlorocebus aethiopsFas Ligand Proteinfas ReceptorHerpesvirus 1, HumanInflammationMaleMice, Inbred BALB CMicrogliaModels, BiologicalNeuronsNeuroprotectionAmyloid beta-PeptidesChemokinesFas Ligand ProteinFas protein, mousefas ReceptorNitric OxideNitric Oxide Synthase Type II

Identifiers

PMID30886672
PMCPMC6388346
OpenAlexW2913532401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.