ArticleFrontiers in immunology2019
Local Antigen Encounter Is Essential for Establishing Persistent CD8
Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Cross-reactive tissue-resident memory T lymphocytes-concepts, evidence, and open questions.Journal of translational medicine · 2026Review
- Living rent free in your head: resident memory T cells.ImmunoHorizons · 2026Review
- CD8CNS neuroscience & therapeutics · 2024Article
- Antigen non-specific CD8bioRxiv : the preprint server for biology · 2024Article
- Osteopontin associates with brain TiScience · 2023Article
- Systemic virus infection results in CD8 T cell recruitment to the retina in the absence of local virus infection.Frontiers in immunology · 2023Article
- Immunological defense of CNS barriers against infections.Immunity · 2022Review
- Lung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts.The Journal of experimental medicine · 2022Article
- Memory CD8Immunology · 2021Article
- Encephalitogenic and Regulatory CD8 T Cells in Multiple Sclerosis and Its Animal Models.Journal of immunology (Baltimore, Md. : 1950) · 2021Review
- Area under Immunosurveillance: Dedicated Roles of Memory CD8 T-Cell Subsets.Cold Spring Harbor perspectives in biology · 2020Review
- Disruption of cellular proteostasis by H1N1 influenza A virus causes α-synuclein aggregation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Memory CD4Cells · 2020Review
- Functionally Competent, PD-1Frontiers in immunology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While the brain is considered an immune-privileged site, the CNS may nevertheless be the focus of immune mediated inflammation in the case of infection and certain autoimmune diseases, e.g., multiple sclerosis. As in other tissues, it has been found that acute T-cell infiltration may be followed by establishment of persistent local T-cell memory. To improve our understanding regarding the regulation of putative tissue resident memory T (Trm) cells in CNS, we devised a new model system for studying the generation of Trm cells in this site. To this purpose, we exploited the fact that the CNS may be a sanctuary for adenoviral infection, and to minimize virus-induced disease, we chose replication-deficient adenoviruses for infection of the CNS. Non-replicating adenoviruses are known to be highly immunogenic, and our studies demonstrate that intracerebral inoculation causes marked local T-cell recruitment, which is followed by persistent infiltration of the CNS parenchyma by antigen specific CD8
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.