ReviewFrontiers in psychiatry2019
Primary Cilia-An Underexplored Topic in Major Mental Illness.
Review in Frontiers in psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Review
- Emerging roles of the ciliary-mitochondrial axis in cellular homeostasis and neuroprotection.Molecular neurodegeneration advances · 2025Article
- Deconvolution-Based Transcriptomic Analysis in the Hippocampus Reveals Cell Type-Specific Risk Genes and Pathways Associated With Depression and Suicide.Biological psychiatry global open science · 2025Article
- Article
- Article
- Ultrastructural differences impact cilia shape and external exposure across cell classes in the visual cortex.Current biology : CB · 2024Article
- An epilepsy-associated CILK1 variant compromises KATNIP regulation and impairs primary cilia and Hedgehog signaling.bioRxiv : the preprint server for biology · 2024Article
- Nanometer-scale views of visual cortex reveal anatomical features of primary cilia poised to detect synaptic spillover.bioRxiv : the preprint server for biology · 2023Article
- Article
- Primary cilia-associated protein IFT172 in ciliopathies.Frontiers in cell and developmental biology · 2023Review
- Primary cilia in the postnatal brain: Subcellular compartments for organizing neuromodulatory signaling.Current opinion in neurobiology · 2022Review
- KIAA0319 influences cilia length, cell migration and mechanical cell-substrate interaction.Scientific reports · 2022Article
- Sex Differences in the Brain Transcriptome Related to Alcohol Effects and Alcohol Use Disorder.Biological psychiatry · 2022Review
- Primary cilia safeguard cortical neurons in neonatal mouse forebrain from environmental stress-induced dendritic degeneration.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Exploring the Impact of Cerebrovascular Disease and Major Depression on Non-diseased Human Tissue Transcriptomes.Frontiers in genetics · 2021Article
- Transcriptional Profiling of Primate Central Nucleus of the Amygdala Neurons to Understand the Molecular Underpinnings of Early-Life Anxious Temperament.Biological psychiatry · 2020Article
- Retinal layer abnormalities and their association with clinical and brain measures in psychotic disorders: A preliminary study.Psychiatry research. Neuroimaging · 2020Article
- DNA Variant in theMolecular neuropsychiatry · 2020Article
- Roles for IFT172 and Primary Cilia in Cell Migration, Cell Division, and Neocortex Development.Frontiers in cell and developmental biology · 2019Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Though much progress has been made in recent years towards understanding the function and physiology of primary cilia, they remain a somewhat elusive organelle. Some studies have explored the role of primary cilia in the developing nervous system, and their dysfunction has been linked with several neurosensory deficits. Yet, very little has been written on their potential role in psychiatric disorders. This article provides an overview of some of the functions of primary cilia in signalling pathways, and demonstrates that they are a worthy candidate in psychiatric research. The links between primary cilia and major mental illness have been demonstrated to exist at several levels, spanning genetics, signalling pathways, and pharmacology as well as cell division and migration. The primary focus of this review is on the sensory role of the primary cilium and the neurodevelopmental hypothesis of psychiatric disease. As such, the primary cilium is demonstrated to be a key link between the cellular environment and cell behaviour, and hence of key importance in the considerations of the nature and nurture debate in psychiatric research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.