ArticleFrontiers in physiology2019
Sudden Unexpected Death and the Mammalian Dive Response: Catastrophic Failure of a Complex Tightly Coupled System.
Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Review
- High density probes reveal medullary seizure and rapid medullary shutdown in a model of fatal apnea in seizure.Epilepsy research · 2025Article
- Autonomic Dysfunction in a Child Who Experienced Drowning Following COVID-19 Infection: A Patient Report.Yonago acta medica · 2025Article
- The Changing Epidemiology of Sudden Infant Death Syndrome: A 15-Year Overview Comparing Italian and European Data.Health science reports · 2025Article
- Snorkelling and Breath-Hold Diving Fatalities in Australia-A Review of 317 Deaths.International journal of environmental research and public health · 2025Review
- Autonomic dysfunction as a possible cause of sudden cardiac death in swimming sports.Frontiers in cardiovascular medicine · 2024Article
- Trigeminal nerve stimulation: a current state-of-the-art review.Bioelectronic medicine · 2023Review
- Sudden unexpected death in epilepsy: A critical view of the literature.Epilepsia open · 2023Review
- Carotid body stimulation as a potential intervention in sudden death in epilepsy.Epilepsy & behavior : E&B · 2022Article
- Utilizing multimodal imaging to visualize potential mechanism for sudden death in epilepsy.Epilepsy & behavior : E&B · 2021Article
- Ictal activation of oxygen-conserving reflexes as a mechanism for sudden death in epilepsy.Epilepsia · 2021Article
- Mechanisms and prevention of acid reflux induced laryngospasm in seizing rats.Epilepsy & behavior : E&B · 2020Article
- The Mammalian Diving Response: Inroads to Its Neural Control.Frontiers in neuroscience · 2020Review
- Sudden death across brain and heart: cardio-cerebral ion channel dysfunction as a potential risk-modifying mechanism linking epilepsy and long QT syndrome.Frontiers in neurologyReview
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In tightly coupled complex systems, when two or more factors or events interact in unanticipated ways, catastrophic failures of high-risk technical systems happen rarely, but quickly. Safety features are commonly built into complex systems to avoid disasters but are often part of the problem. The human body may be considered as a complex tightly coupled system at risk of rare catastrophic failure (sudden unexpected death, SUD) when certain factors or events interact. The mammalian dive response (MDR) is a built-in safety feature of the body that normally conserves oxygen during acute hypoxia. Activation of the MDR is the final pathway to sudden cardiac (SCD) in some cases of sudden infant death syndrome (SIDS), sudden unexpected death in epilepsy (SUDEP), and sudden cardiac death in water (SCDIW, fatal drowning). There is no single cause in any of these death scenarios, but an array of, unanticipated, often unknown, factors or events that activate or interact with the mammalian dive reflex. In any particular case, the relevant risk factors or events might include a combination of genetic, developmental, metabolic, disease, environmental, or operational influences. Determination of a single cause in any of these death scenarios is unlikely. The common thread among these seemingly different death scenarios is activation of the mammalian dive response. The human body is a complex tightly coupled system at risk of rare catastrophic failure when that "safety feature" is activated.
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