ArticleNature neuroscience2019
A whole-brain atlas of monosynaptic input targeting four different cell types in the medial prefrontal cortex of the mouse.
Article in Nature neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 137 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
137 citing papers in PubMed, 2 syntheses or guidelines pooled it, 236 citations in OpenAlex.
- Structural and functional organization of the midline and intralaminar nuclei of the thalamus.Frontiers in behavioral neuroscience · 2022Pooled it
- Connectivity and Functionality of the Globus Pallidus Externa Under Normal Conditions and Parkinson's Disease.Frontiers in neural circuits · 2021Pooled it
- Extinction-recruited prefrontal-hypothalamic pathway encodes positive affect to sustain fear extinction in posttraumatic stress mouse model.The Journal of clinical investigation · 2026Article
- Loss of Fmr1 causes subnucleus-specific decreases in dendritic complexity in mediodorsal thalamus.Brain structure & function · 2026Article
- Brain-wide atlas of outputs and inputs of mouse auditory cortex revealed by modified viral labeling strategies.Fundamental research · 2026Article
- ATP release from the amygdala-prefrontal pathway regulates vulnerability to social stress in male mice.Molecular psychiatry · 2026Article
- An olfactory-prefrontal cortical circuit supports social recognition.Research square · 2026Article
- GluK1 kainate receptors in parvalbumin interneurons modulate cortico-hippocampal network dynamics during social behavior.Translational psychiatry · 2026Article
- Nps-Expressing Neurons Receive Extensive Input From Auditory Brainstem Nuclei.The Journal of comparative neurology · 2026Article
- A prefrontal cortex map based on single-neuron activity.Nature neuroscience · 2026Article
- DMC-BrainMap is an open-source, end-to-end tool for multi-feature brain mapping in different species.Cell reports methods · 2026Article
- Article
- Multiple-Context Training Enhances Generalization of Cued Fear Extinction and Requires the Dorsal Hippocampus.bioRxiv : the preprint server for biology · 2026Article
- Mapping prefrontal afferents along development.Frontiers in neuroscience · 2026Article
- Development and application of a barcoded rabies viral tracing method for mapping brain-wide inputs to single neurons.Cell reports methods · 2025Article
- Medial prefrontal cortex circuit dynamics involved in stage-specific addiction.Brain structure & function · 2025Review
- Convergent Control of NREM Sleep and Anesthesia by Prefrontal Layer 5 Extratelencephalic Neurons.Research square · 2025Article
- Article
- A lateral hypothalamic neuronal population expressing leptin receptors counteracts anxiety to enable adaptive behavioral responses.Nature neuroscience · 2025Article
- NPS neurons receive extensive input from auditory brainstem nuclei.bioRxiv : the preprint server for biology · 2025Article
77 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The local and long-range connectivity of cortical neurons are considered instrumental to the functional repertoire of the cortical region in which they reside. In cortical networks, distinct cell types build local circuit structures enabling computational operations. Computations in the medial prefrontal cortex (mPFC) are thought to be central to cognitive operation, including decision-making and memory. We used a retrograde trans-synaptic rabies virus system to generate brain-wide maps of the input to excitatory neurons as well as three inhibitory interneuron subtypes in the mPFC. On the global scale the input patterns were found to be mainly cell type independent, with quantitative differences in key brain regions, including the basal forebrain. Mapping of the local mPFC network revealed high connectivity between the different subtypes of interneurons. The connectivity mapping gives insight into the information that the mPFC processes and the structural architecture underlying the mPFC's unique functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.